| Yiliyaer,Yusufu Maimaiti. Aurora kinases: novel anti-breast cancer targets. Oncol Transl Med, 2019, 5: 43-48. |
| 新型抗乳腺癌靶点和药物：极光激酶和抑制剂 |
| Aurora kinases: novel anti-breast cancer targets |
| Received:November 07, 2018 Revised:March 02, 2019 |
| DOI：10.1007/s10330-018-0315-5 |
| 中文关键词: 极光激酶；乳腺癌；过量表达 |
| 英文关键词: aurora kinases; breast cancer; inhibitors |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Yiliyaer* | xinjiang medical university | 2476787631@qq.com | | Yusufu Maimaiti* | People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, China | |
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| 中文摘要: |
| 极光激酶（AKS）调节真核细胞中有丝分裂细胞的多个成分。它在细胞周期的调控中起着重要的作用，与多种肿瘤的肿瘤发生有关。在一些肿瘤细胞中观察到极光激酶的过度表达，并且已经证明极光激酶的异常与肿瘤的发生密切相关。极光激酶在乳腺癌细胞中经常被扩增或过表达，导致染色体异常分离、基因组不稳定和致癌途径的激活。目前，在多期I和II期研究中，新的奥罗拉激酶抑制剂正在研究中。本文就极光激酶在乳腺癌细胞中的生物学功能及作用机制作一综述，并总结乳腺癌中极光激酶抑制剂的临床前研究结果。 |
| 英文摘要: |
| Aurora kinases regulate multiple steps of mitotic cell division in eukaryotic cells. Overexpression of aurora
kinases has been observed in some tumor cells, which suggests that abnormalities in aurora kinases
are closely related to tumorigenesis. In additon, aurora kinases are often amplified or overexpressed in
breast cancer cells, leading to chromosomal segregation abnormalities and genomic disorder, and thereby
activating oncogenic pathways. Novel Aurora A kinase inhibitors are currently being studied in multiple phase
I and II studies. In this review, we describe the biological functions and mechanisms of aurora kinases in
breast cancer cells and summarize the preclinical findings related to aurora kinases in breast cancer. |
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