| shaojunnong,Yangbo Guan,Zhiwei Wang,Zhongqing Wei,Yueping Zhang,Jian Ni,Chongsheng He,Limin Ma,Shujun Zhou,Wenguang Li. Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients. Oncol Transl Med, 2018, 4: 247-254. |
| IL-18 and NANOG基因多态性在前列腺癌临床易感性的临床研究 |
| Clinical study of IL-18 and NANOG gene polymorphisms in prostate cancer patients |
| Received:October 13, 2018 Revised:January 22, 2019 |
| DOI：10.1007/s10330-018-0308-8 |
| 中文关键词: 关键词：白细胞介素18；Nanog基因；基因多态性；前列腺癌；临床特征 |
| 英文关键词: interleukin (IL)-18;Nanog gene; polymorphism; prostate cancer; clinical characteristics |
| 基金项目:中国博士后科学基金 |
| Author Name | Affiliation | E-mail | | shaojunnong* | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | shaojunnong@sina.com | | Yangbo Guan | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | | | Zhiwei Wang | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | | | Zhongqing Wei | The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China. | | | Yueping Zhang | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | | | Jian Ni | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | | | Chongsheng He | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | | | Limin Ma | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China ,China. | | | Shujun Zhou | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | | | Wenguang Li | Department of Urological Surgery, The Affiliated Hospital of Nantong University, Nantong 226001, China | |
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| 中文摘要: |
| 目的 最近的研究显示Nanog和白细胞介素-18基因的异常表达和肿瘤有关。但对于Nanog和白细胞介素-18基因多态性在前列腺癌的分子机制仍不明确。本研究探讨Nanog和白细胞介素-18基因多态性及其相互作用在汉族人前列腺癌发展中临床病理分期的相关性和易感性。
方法：检测Nanog和白细胞介素-18基因多态性在120例前列腺患者的易感性。其中对照组为125名汉族人。采用TaqMan等位基因鉴定试剂分析进行基因分型。采用SPSS软件进行统计学分析。
结果：Nanog和白细胞介素-18基因多态性和整个前列腺癌的肿瘤易感性无关联。IL-18-607 CC基因分型和肿瘤的分级、分期有显著关联（P 分别为0.025和 0.001）。IL-18-137 GG基因分型和肿瘤的分级、分期有关（P分别为0.028、0.008）。IL-18-137G等位基因在淋巴结转移的患者有显著的异常（P = 0.035）。而IL-18-607 CC基因分型和肿瘤的远处转移有关（P = 0.025）。但，没有发现Nanog基因多态性和肿瘤分级、分期有相关性。Cox 风险评估模型显示在肿瘤的分级和分期中白细胞介素-18是独立的预后因子，而不是白细胞介素18的基因多态性。但Nanog（AC分型）和白细胞介素-18（IL-18-607和 IL-18-137）基因多态性的变异和较差的肿瘤预后相关。
结论：Nanog基因变异可能和前列腺癌的早期发病机制有关。Nanog和白细胞介素-18基因多态性可能参与在前列腺癌的发生、浸润和转移作用。 |
| 英文摘要: |
| Objective?Recent studies have shown abnormal expression of NANOG and IL-18 to be related to cancer. However, the molecular mechanism by which IL-18 and NANOG gene polymorphisms are associated with prostate cancer is unclear. In this study, we examined whether IL-18 and NANOG gene polymorphisms and their interaction with prostate cancer-related risk factor are associated with the susceptibility to and clinicopathological development of prostate cancer among Chinese men.
Methods?Polymorphisms in the NANOG and IL-18 genes were evaluated for susceptibility in 120 patients with prostate cancer. The control group consisted of 125 samples from Chinese men. Genotyping was conducted using TaqMan allelic discrimination assays. Statistical analysis was performed using SPSS software.
Results?No association of NANOG and IL-18 gene polymorphisms and overall prostate cancer susceptibility was detected. The IL-18-607 CC genotype was significantly associated with a higher tumor grade (P = 0.025) and stage (P =0.001). The IL-18-137 GG genotype correlated with a higher tumor grade (P = 0.028) and stage (P = 0.008). The IL-18-137G allele was significantly more frequent in patients with lymph node metastasis (P = 0.035). The IL-18-607 CC genotype was associated with distant metastasis (P = 0.025). However, no significant association was observed between NANOG polymorphisms and any clinicopathological feature. The Cox proportional hazard model showed that tumor grade and stage grouping were independent prognostic factors in IL-18, while IL-18 polymorphism was not. Polymorphism variants in the IL-18 (IL-18-607 and IL-18-137) and NANOG (genotypes AC) genes might be associated with a worse prognosis of patients with prostate cancer.
Conclusion?NANOG may be associated with the early stages of prostate cancer carcinogenesis. IL-18 and NANOG gene polymorphisms may play a major role in the growth, invasion, and metastasis of prostate cancer.
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