| Lingjun Meng,Fangzhen Shen. Expression and clinical significance of serum lipoprotein (a) in patients with gastric cancer. Oncol Transl Med, 2018, 4: 242-246. |
| 血清脂蛋白a在胃癌患者中的表达及临床意义 |
| Expression and clinical significance of serum lipoprotein (a) in patients with gastric cancer |
| Received:October 12, 2018 Revised:January 08, 2019 |
| DOI：10.1007/s10330-018-0307-7 |
| 中文关键词: 脂蛋白（a）；胃癌；分期；分化；病理分型 |
| 英文关键词: lipoprotein (a) [LP (a)]; gastric cancer; staging; differentiation; pathological typing |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨血清脂蛋白a【Lipoprotein(a)】在胃癌患者中的表达及临床意义。方法 1、选取本院2015-2017年的222例胃癌患者(胃癌组)（平均年龄58.40 岁，范围± 10.40岁），及同期101名健康查体者(正常组) （平均年龄58.18 岁，范围± 11.42岁），抽取空腹血，应用生化分析仪采用免疫比浊法测定，观察血清脂蛋白 a 浓度，比较其差异。结果 1、LP（a）水平与肿瘤分期无明显相关性（P＞0.05）；2、LP（a）水平在男性胃癌组与对照组相比，胃癌组明显高于对照组（P＜0.05）；3、亚组分析，I 期-IV期胃癌患者脂蛋白 a 水平及异常率呈递增趋势；4、低分化胃癌患者LP（a）水平高于高-中分化组患者（P＜0.05）；5、在不同胃癌病理分型患者中LP（a）水平无统计学差异（P＞0.05）。结论 Lp(a)与胃癌的发生、发展及分化程度有相关性，与胃癌病理分型无明显相关性。Lp(a)血清浓度可能能作为分析胃癌分期与预后的指标，但具体机制还有待进一步研究。 |
| 英文摘要: |
| Objective: This study aimed to investigate the expression and clinical significance of serum lipoprotein (a)
[LP (a)] in patients with gastric cancer.
Methods: Two hundred and twenty-two patients with gastric cancer (gastric cancer group) were selected
from 2015 to 2017 [mean age (58.40 ± 10.40) years], as were 101 healthy persons [normal age group, mean
age (58.18 ± 11.42) years]. Fasting blood samples were collected and evaluated by immunoturbidimetry
with a biochemical analyzer. LP (a) concentration was observed and its difference was compared.
Results: There was no significant correlation between LP (a) and tumor stage (P > 0.05). Compared with
the control group, the level of LP (a) in the male gastric cancer group was significantly higher than that in
the control group (P < 0.05). In the subgroup analysis, the level of LP (a) and abnormal rate showed an
increasing trend among patients with stages I–IV gastric cancer. The level of LP (a) in poorly differentiated
gastric cancer patients was higher than that in the high middle differentiation group (P < 0.05). There was
no significant difference in LP (a) levels among patients with different pathological types of gastric cancer
(P > 0.05).
Conclusion: LP (a) was correlated with the occurrence, development and differentiation of gastric cancer,
but not with the pathological classification of gastric cancer. Serum LP (a) concentration may be used as
an indicator for the staging and prognosis of gastric cancer, but the specific underlying mechanism remains
to be further studied. |
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