| Xiaozhen Zhan,Weidong Wu,Kezhen Wang,Xinmin Wang,Jiyong Leng,Chengzhi Cui,Peiyu Cong. Metastatic intracranial large-cell neuroendocrine carcinoma: a study of two cases. Oncol Transl Med, 2018, 4: 255-258. |
| Metastatic intracranial large-cell neuroendocrine carcinoma: a study of two cases |
| Received:October 11, 2018 Revised:January 11, 2019 |
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| KeyWord:large cell neuroendocrine carcinoma; intracranial; neuroendocrine tumor; prognosis |
| Author Name | Affiliation | E-mail | | Xiaozhen Zhan | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China
Dalian Medical University, Dalian 116044, China. | 17605054233@163.com | | Weidong Wu | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Kezhen Wang | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Xinmin Wang | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Jiyong Leng | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Chengzhi Cui | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | cuichengzhi2001@sina.com | | Peiyu Cong | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | congpeiyu1964@163.com |
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| Abstract: |
| Objective?The occurrence of large-cell neuroendocrine carcinoma (LCNEC), a kind of neuroendocrine tumor (NET), in the cranium is extremely rare. Here we report two such cases and review the literature in order to improve the diagnosis and treatment of intracranial LCNEC.
Methods?We report two cases of metastatic intracranial LCNEC. In case 1, the patient was diagnosed with lung carcinoma and underwent chemotherapy. Brain metastases were found six months later. The lung and intracranial lesions in case 2 were found at the same time.
Results?Intracranial multiple-tumor resection was performed in case 1 and the patient died 2 months later. Case 2 patient underwent surgery followed by chemotherapy with etoposide and carboplatin. Six months postoperatively, a recurrence lesion was found in the left cerebellar hemisphere. The patient was treated surgically. At present, a year after the diagnosis, the patient is still alive.
Conclusion?NETs of the intracranial region are extremely rare, and hence, most of our knowledge is based on lung NETs, and standard treatment strategies for intracranial NETs remain unclear. Our patients had different survival times probably due to different treatments, indicating that effective surgical resection and subsequent multi-agent chemotherapy should be administered to promote long-term survival of intracranial LCNEC patients.
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