| Xiaozhen Zhan,Weidong Wu,Kezhen Wang,Xinmin Wang,Jiyong Leng,Chengzhi Cui,Peiyu Cong. Metastatic intracranial large-cell neuroendocrine carcinoma: a study of two cases. Oncol Transl Med, 2018, 4: 255-258. |
| 颅内转移性大细胞癌2例 |
| Metastatic intracranial large-cell neuroendocrine carcinoma: a study of two cases |
| Received:October 11, 2018 Revised:January 11, 2019 |
| DOI：10.1007/s10330-018-0306-6 |
| 中文关键词: 大细胞癌、颅脑、神经内分泌瘤、预后 |
| 英文关键词: large cell neuroendocrine carcinoma; intracranial; neuroendocrine tumor; prognosis |
| 基金项目:无 |
| Author Name | Affiliation | E-mail | | Xiaozhen Zhan | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China
Dalian Medical University, Dalian 116044, China. | 17605054233@163.com | | Weidong Wu | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Kezhen Wang | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Xinmin Wang | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Jiyong Leng | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | | | Chengzhi Cui | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | cuichengzhi2001@sina.com | | Peiyu Cong* | Department of Neurosurgery, Dalian Municipal Central Hospital, Dalian 116033, China | congpeiyu1964@163.com |
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| 中文摘要: |
| 目标大细胞癌是一种神经内分泌瘤，极少发生在颅脑。我们报道2例大细胞癌，以提高对颅内大细胞啊对诊断和治疗。
方法 我们报告2例转移性颅内大细胞癌病例，病例1诊断为肺癌并接受了化疗，6个月后发现颅内转移。病例2同时发现肺内及颅内占位。
结果 病例1接受了手术治疗，两个月后死亡。病例2接受了手术治疗，并在术后进行了依托泊苷+卡铂化疗，术后6个月，左侧小脑半球复发了大细胞癌，患者又接受了手术治疗。直至目前为止，患者确诊后1年仍然存活。
结论 颅内神经内分泌癌极少见，大部分了解都是基于肺内分泌癌。颅内神经内分泌癌的标准治疗方案尚不明确，但我们的病例接受不同的治疗方案并获得不同的生存期，所以我们建议行手术治疗联合辅助化疗以延长颅内神经细胞癌患者生存寿命。 |
| 英文摘要: |
| Objective?The occurrence of large-cell neuroendocrine carcinoma (LCNEC), a kind of neuroendocrine tumor (NET), in the cranium is extremely rare. Here we report two such cases and review the literature in order to improve the diagnosis and treatment of intracranial LCNEC.
Methods?We report two cases of metastatic intracranial LCNEC. In case 1, the patient was diagnosed with lung carcinoma and underwent chemotherapy. Brain metastases were found six months later. The lung and intracranial lesions in case 2 were found at the same time.
Results?Intracranial multiple-tumor resection was performed in case 1 and the patient died 2 months later. Case 2 patient underwent surgery followed by chemotherapy with etoposide and carboplatin. Six months postoperatively, a recurrence lesion was found in the left cerebellar hemisphere. The patient was treated surgically. At present, a year after the diagnosis, the patient is still alive.
Conclusion?NETs of the intracranial region are extremely rare, and hence, most of our knowledge is based on lung NETs, and standard treatment strategies for intracranial NETs remain unclear. Our patients had different survival times probably due to different treatments, indicating that effective surgical resection and subsequent multi-agent chemotherapy should be administered to promote long-term survival of intracranial LCNEC patients.
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