| Xiaoying Quan,Pinjia Wang,Lei Lei,Xiaoyan Chen,Chunzhi Wu,Bin Ye,Zhihui Zhang. Analysis of clinical efficacy of P-Gemox regimen sandwich radiotherapy, P-Gemox regimen sequential radiotherapy, and radiotherapy alone treatment for extranodal natural killer/T-cell lymphoma. Oncol Transl Med, 2018, 4: 185-195. |
| P-Gemox夹心放疗，P-Gemox序贯放疗以及单纯放疗治疗结外NK/T细胞淋巴瘤的疗效分析 |
| Analysis of clinical efficacy of P-Gemox regimen sandwich radiotherapy, P-Gemox regimen sequential radiotherapy, and radiotherapy alone treatment for extranodal natural killer/T-cell lymphoma |
| Received:September 30, 2018 Revised:November 16, 2018 |
| DOI：10.1007/s10330-018-0304-4 |
| 中文关键词: 培门冬酶；结外NK/T细胞淋巴瘤；预后 |
| 英文关键词: pegaspargase; natural killer/T-cell lymphoma; prognosis |
| 基金项目:四川省卫生厅科学研究项目（编号：090528） |
| Author Name | Affiliation | E-mail | | Xiaoying Quan | Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu 610051, China | 1193084163@qq.com | | Pinjia Wang | Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu 610051, China | | | Lei Lei | Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu 610051, China | | | Xiaoyan Chen | Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu 610051, China | | | Chunzhi Wu | Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu 610051, China | | | Bin Ye | Department of Medical Oncology, The Sixth People's Hospital of Chengdu, Chengdu 610051, China | | | Zhihui Zhang* | Department of Medical Oncology, Sichuan Cancer Hospital and Research Institute, Chengdu 610041, China | 13881889731@139.com |
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| 中文摘要: |
| 目的：探讨P-Gemox夹心放疗，P-Gemox序贯放疗以及单纯放疗治疗结外NK/T细胞淋巴瘤的疗效。方法：回顾性分析2009年6月～2016年1月初治的124例早期结外NK/T细胞淋巴瘤患者的临床资料，比较三种治疗模式的临床疗效。结果：46例患者选择P-Gemox夹心放疗，CR为91.3%，ORR为97.8%，2年PFS为76.1%，2年OS为80.4%。37例患者采用P-Gemox方案序贯放疗，CR为86.5%，ORR为94.6%，2年PFS为75.7%，2年OS为81.1%。41例患者行单纯放疗，CR为61.0%，ORR为80.5%，2年PFS为51.2%，2年OS为65.9%。两两比较显示，单纯放疗与夹心放疗组，序贯放疗组的CR，PFS和OS比较差异均有统计学意义(P＜0.05)。但是，夹心放疗组与序贯放疗组的CR，ORR，PFS，OS差异无统计学意义(P＞0.05)。多因素分析显示：ECOG，LDH，血小板淋巴细胞比值(platelet to lymphocyte ratio, PLR)，局部肿瘤浸润及治疗模式是影响PFS的独立预后因素(P＜0.05)。而ECOG，LDH，PLR，局部肿瘤浸润，合并基础疾病及治疗模式是影响OS的独立预后因素(P＜0.05)。结论: P-Gemox化疗方案联合放疗治疗早期结外NK/T细胞淋巴瘤优于单纯放疗。 |
| 英文摘要: |
| Objective The study aimed to explore the clinical efficacy of P-Gemox regimen sandwich radiotherapy,
P-Gemox regimen sequential radiotherapy, and radiotherapy alone in early-stage extranodal natural killer/
T-cell lymphoma (ENKTL).
Methods In total, 124 patients with early-stage ENKTL, from June 2009 to January 2016, were
retrospectively analyzed to compare the clinical efficacy of the three regimens.
Results A total of 46 patients were treated with P-Gemox regimen sandwich radiotherapy, with complete
remission (CR) of 91.3%, objective response rate (ORR) of 97.8%, 2-year progression-free survival
(PFS) of 76.1%, and 2-year overall survival (OS) of 80.4%. Then, 37 patients received P-Gemox regimen
sequential radiotherapy, with CR of 86.5%, ORR of 94.6%, 2-year PFS of 75.7%, and 2-year OS of 81.1%.
Finally, 41 patients received radiotherapy alone, with CR of 61.0%, ORR of 80.5%, 2-year PFS of 51.2%,
and 2-year OS of 65.9%. When the two groups were compared, significant differences in CR, PFS, and
OS were observed among the sandwich radiotherapy, sequential radiotherapy, and radiotherapy alone
groups (P < 0.05), respectively. However, no significant difference in CR, ORR, PFS, and OS was observed
between the sandwich radiotherapy and sequential radiotherapy groups (P > 0.05). Multivariate analysis
revealed that Eastern Cooperative Oncology Group (ECOG), serum lactate dehydrogenase (LDH), plateletto-lymphocyte ratio (PLR), local tumor invasion, and treatment modalities were independent prognostic
factors for PFS (P < 0.05). ECOG, LDH, PLR, local tumor invasion, underlying disease, and treatment
modalities were independent prognostic factors for OS (P < 0.05).
Conclusion P-Gemox regimen combination radiotherapy for patients with early-stage ENKTL was better
than the radiotherapy alone. |
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