| Lei Zhou,Dongbo Liu. Local definitive intensity-modulated radiation therapy recommended for patients initially diagnosed with nasopharyngeal carcinoma with distant metastasis after an effective systemic chemotherapy. Oncol Transl Med, 2018, 4: 234-237. |
| 初诊转移性鼻咽癌在有效的全身化疗后应给予根治性局部放疗 |
| Local definitive intensity-modulated radiation therapy recommended for patients initially diagnosed with nasopharyngeal carcinoma with distant metastasis after an effective systemic chemotherapy |
| Received:August 30, 2018 Revised:October 19, 2018 |
| DOI：10.1007/s10330-018-0294-4 |
| 中文关键词: 鼻咽癌，转移，调强放疗 |
| 英文关键词: nasopharyngeal carcinoma (NPC); metastasis; intensity-modulated radiation therapy (IMRT) |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Lei Zhou | Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | dbliutj@163.com | | Dongbo Liu* | Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | dbliutj@163.com |
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| 中文摘要: |
| 既往认为初诊的转移性鼻咽癌是不可治愈的。全身化疗是最主要的治疗手段，但治疗后中位生存期仅有12-20个月。对鼻咽原发病灶和颈部病灶的放疗剂量往往是姑息性的。所以这种放疗模式往往并不能改善患者生存。最近的一些研究显示对于初诊转移性鼻咽癌，在全身化疗基础上联合局部根治性放疗可以延长患者生存期。因此我们建议对于初诊的转移性鼻咽癌患者，在采用有效的全身化疗后应该给予局部根治性调强放疗。 |
| 英文摘要: |
| Objective: The aim of the study was to propose a hypothesis that local definitive intensity-modulated radiation therapy (IMRT) should be recommended for initially diagnosed metastatic nasopharyngeal carcinoma (NPC) and demonstrate its feasibility. Methods: Recently published papers on local definitive radiotherapy for initially diagnosed metastatic NPC were reviewed to propose a hypothesis. Results: Several studies revealed the survival benefits of adding local definitive radiotherapy to the systemic chemotherapy in patients initially diagnosed with metastatic NPC. Conclusion: We suggested that local definitive IMRT should be recommended in patients initially diagnosed with NPC with distant metastasis after an effective systemic chemotherapy, which may possibly prolong their survival time and potentially treat the disease. |
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