| Xiaoli Zou,Baixin Sun,Li Jia,Xiaobei Liu. The clinical study of ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute combined with HIFU in the treatment of uterine fibroids. Oncol Transl Med, 2018, 4: 203-207. |
| 无水乙醇肌瘤内注射联合HIFU 治疗子宫肌瘤的临床研究 |
| The clinical study of ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute combined with HIFU in the treatment of uterine fibroids |
| Received:August 23, 2018 Revised:October 21, 2018 |
| DOI：10.1007/s10330-018-0292-2 |
| 中文关键词: 高强度聚焦超声; 无水乙醇; 子宫肌瘤; 能效因子 |
| 英文关键词: high-intensity focused ultrasonography (HIFU); absolute ethyl alcohol; hysteromyomas; uterine fibroids; energy efficiency factor |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xiaoli Zou | Dalian Municipal Friendship Hospital | 1324470905@qq.com | | Baixin Sun | Dalian Municipal Friendship Hospital | | | Li Jia | The Affiliated Dalian Friendship Hospital of Dalian Medicial University | | | Xiaobei Liu* | Dalian Municipal Friendship Hospital | 13942077177@139.com |
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| 中文摘要: |
| 目的 探讨无水乙醇肌瘤内注射能否增加高强度聚焦超声( HIFU) 靶区能量沉积，缩短治疗时间，提高治疗效率，降低患者疼痛和并发症的发生。方法 80 例子宫肌瘤患者随机分成HIFU 组( H 组) 和无水乙醇联合HIFU 治疗组( E+H组) ，E+H 组于HIFU 治疗前1 h 行超声引导下无水乙醇肌瘤内注射，比较两组HIFU 消融辐照时间、辐照剂量、能效因子( EEF: 消融单位体积所需辐照能量) ，灰度变化以及两组患者治疗疼痛评分和不良反应。结果 E+H 组HIFU 辐照时间、辐照剂量、能效因子明显低于H 组( P＜0. 05) ，E+H 组以团块状强回声为主，H 组以非团块状强回声为主，治疗疼痛评分及不良反应发生率也高于E+H 组。结论 无水乙醇肌瘤内注射能够增强HIFU 能量在子宫肌瘤内部的沉积，提高HIFU 治疗效率，缩短治疗时间，减少治疗剂量，减轻患者疼痛及并发症的发生。 |
| 英文摘要: |
| Objective The aim of this study was to investigate the energy deposition in the target area of high intensity
focused ultrasound (HIFU) with ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute
Methods Eighty patients with hysteromyomas were randomly divided into two groups: group HIFU
(group H) and group HIFU combined with ultrasound-guided intra-hysteromyoma injectionn of ethyl alcohol
absolute (group E H). Patients in group E H received an ultrasound-guided injection of absolute ethyl
alcohol 1 h before HIFU treatment. The irradiation time, irradiation dose, energy efficiency factor (radiation
energy required for ablation of a myoma per unit of volume), grey variation, pain score, and adverse
reactions were compared between the two groups. An independent sample t-test was used with a twotailed P-value of < 0.05.
Results The irradiation time, irradiation dose, and energy efficiency factor were significantly lower in
group E H than those in group H (P < 0.05). The hysteromyomas of patients in group E H appeared as
dominantly hyperechoic masses, and those of patients in group H appeared as hyperechoic tissue (nonmass). The incidence of adverse reactions and pain score were higher in group H than those in group E
H (P < 0.05).
Conclusion Ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute can enhance the
energy deposition of HIFU in the uterine fibroids, improve the treatment efficiency, shorten the treatment
time, reduce the treatment dose, and reduce the pain and complications for the patients. |
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