| Xiaoli Zou,Baixin Sun,Li Jia,Xiaobei Liu. The clinical study of ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute combined with HIFU in the treatment of uterine fibroids. Oncol Transl Med, 2018, 4: 203-207. |
| The clinical study of ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute combined with HIFU in the treatment of uterine fibroids |
| Received:August 23, 2018 Revised:October 21, 2018 |
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| KeyWord:high-intensity focused ultrasonography (HIFU); absolute ethyl alcohol; hysteromyomas; uterine fibroids; energy efficiency factor |
| Author Name | Affiliation | E-mail | | Xiaoli Zou | Dalian Municipal Friendship Hospital | 1324470905@qq.com | | Baixin Sun | Dalian Municipal Friendship Hospital | | | Li Jia | The Affiliated Dalian Friendship Hospital of Dalian Medicial University | | | Xiaobei Liu | Dalian Municipal Friendship Hospital | 13942077177@139.com |
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| Abstract: |
| Objective The aim of this study was to investigate the energy deposition in the target area of high intensity
focused ultrasound (HIFU) with ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute
Methods Eighty patients with hysteromyomas were randomly divided into two groups: group HIFU
(group H) and group HIFU combined with ultrasound-guided intra-hysteromyoma injectionn of ethyl alcohol
absolute (group E H). Patients in group E H received an ultrasound-guided injection of absolute ethyl
alcohol 1 h before HIFU treatment. The irradiation time, irradiation dose, energy efficiency factor (radiation
energy required for ablation of a myoma per unit of volume), grey variation, pain score, and adverse
reactions were compared between the two groups. An independent sample t-test was used with a twotailed P-value of < 0.05.
Results The irradiation time, irradiation dose, and energy efficiency factor were significantly lower in
group E H than those in group H (P < 0.05). The hysteromyomas of patients in group E H appeared as
dominantly hyperechoic masses, and those of patients in group H appeared as hyperechoic tissue (nonmass). The incidence of adverse reactions and pain score were higher in group H than those in group E
H (P < 0.05).
Conclusion Ultrasound-guided intra-hysteromyoma injection of ethyl alcohol absolute can enhance the
energy deposition of HIFU in the uterine fibroids, improve the treatment efficiency, shorten the treatment
time, reduce the treatment dose, and reduce the pain and complications for the patients. |
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