| Huili Luo,Ruijie Chang,Xiulan Chen. Long noncoding RNAs as diagnostic biomarkers. Oncol Transl Med, 2018, 4: 151-157. |
| Long noncoding RNAs as diagnostic biomarkers |
| Long noncoding RNAs as diagnostic biomarkers |
| Received:August 12, 2018 Revised:August 26, 2018 |
| DOI：10.1007/s10330-018-0291-1 |
| 中文关键词: LncRNA; Cancer; Biomarker |
| 英文关键词: LncRNA; cancer; biomarker |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Huili Luo | Medical Laboratory Technology, Shiyan Maternal and Child Health Hospital, Shiyan 442000, China | 1505412104@qq.com | | Ruijie Chang | Department of Anesthesiology, Shiyan Taihe Hospital, The Affiliated Hospital of Hubei University of Medicine,Shiyan 442000, China | | | Xiulan Chen* | Shiyan maternal and child health hospital, No. 62 People North Road, Shi Yan, China | 1270061917@qq.com |
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| 中文摘要: |
| Increasing evidence suggests that long noncoding RNA (lncRNAs) play vital roles in the transformation and maintenance of cancer phenotypes, and have important clinical implications. These lncRNAs control important aspects of tumor biology effects including proliferation, angiogenesis, metastasis, and microenvironment via regulating RNA and protein interactions or through their ability to basepair with RNA and DNA.SIn this work, we review the novel mechanism of the cancer-associated lncRNAs’ function and the diagnostic roles in phenotypes of cancer, which will make them attractive in the search of non-invasive biomarkers from body fluid samples in different types of cancer. |
| 英文摘要: |
| Increasing evidence suggests that long noncoding RNAs (lncRNAs) play vital roles in the transformation
and maintenance of cancer phenotypes and have important clinical implications. These lncRNAs
control important aspects of tumor biology, including proliferation, angiogenesis, metastasis, and the
microenvironment by regulating RNA and protein interactions or through their ability to base pair with
RNA and DNA. In this study, we review the mechanism of the function of lncRNAs in cancer and their
diagnostic roles in cancer phenotypes, which make them attractive as non-invasive biomarkers from body
fluid samples for different types of cancer. |
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