| Haining Meng,Junyu Wu,Qiao Huang,Jiwen Ren,Jiawei Huang,Weijun Yuan,Xuekun He,Yuhuan Wang,Congxian Cui,Shengwei Xu,Ruowu Shen. The effects of miR-375 expression in NSCLC via the 14-3-3ζ/ERK/MYC pathway. Oncol Transl Med, 2018, 4: 196-202. |
| The effects of miR-375 expression in NSCLC via the 14-3-3ζ/ERK/MYC pathway |
| Received:August 06, 2018 Revised:November 26, 2018 |
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| KeyWord:NSCLC; miR-375; 14-3-3ζ; ERK; MYC |
| Author Name | Affiliation | E-mail | | Haining Meng | Qingdao University | 1535891698@qq.com | | Junyu Wu | Qingdao University | | | Qiao Huang | Qingdao University | | | Jiwen Ren | Qingdao University | | | Jiawei Huang | Qingdao University | | | Weijun Yuan | Qingdao University | | | Xuekun He | Qingdao University | | | Yuhuan Wang | Qingdao University | | | Congxian Cui | Affiliated Hospital of Qingdao University | | | Shengwei Xu | The third people’s hospital of Qingdao | | | Ruowu Shen | Qingdao University | shenruowu@aliyun.com |
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| Abstract: |
| Objective There are several reports that suggest a significant role played by microRNAs (miRNAs) in
cell invasion, metastasis, differentiation, and apoptosis in lung cancers. miR-375 is one such miRNA that
has been detected in a variety of tumors, but its specific activity in non-small cell lung cancer (NSCLC)
remains unclear.
Methods In this study, we regulated the expression of miR-375, to evaluate its influence on the 14-3-3ζ/
ERK/MYC pathway in NSCLC.
Results The results of our experiments suggest that miR-375 and 14-3-3ζ are highly expressed in
NSCLC, and the over-expression of miR-375 increases the invasive, metastatic, and proliferative ability and
decreases the apoptotic ability of NSCLC cells. In addition, protein expression levels of 14-3-3ζ, p-ERK,
and MYC increased following the overexpression of miR-375.
Conclusion Overall, our findings indicate that miR-375 increases the malignant potential of NSCLC via
the 14-3-3ζ/ERK/MYC pathway. |
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