| Ting Zhou,Shiying Yu. Advances in the diagnosis and treatment of patients. Oncol Transl Med, 2018, 4: 133-143. |
| Advances in the diagnosis and treatment of patients |
| Received:June 08, 2018 Revised:August 27, 2018 |
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| KeyWord:cachexia; malignant tumor; molecular mechanism; staging and diagnosis; treatment |
| Author Name | Affiliation | E-mail | | Ting Zhou | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 446545093@qq.com | | Shiying Yu | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | syyu@tjh.tjmu.edu.cn |
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| Abstract: |
| Cachexia is a common complication with an incidence rate of 50%–80% in cancer patients. It is also
responsible for 20% of mortality among these patients. Cachexia can significantly reduce the efficacy of
antitumor therapies and increase treatment-related toxicity and adverse effects in cancer patients. This
increases the symptom burden in patients, affects their quality of life, and ultimately shortens their survival
time. The mechanism underlying the development of cachexia is complex and diverse and involves various
factors and pathways, each playing an important role. Treatment approaches for cachexia are multimodal,
including nutrition support therapy, appetite stimulants, and therapeutic drugs that specifically target
the mechanism behind the disease. In recent years, we have gradually gained a better understanding
of cachexia, and significant progress has been made in delineating molecular mechanisms, staging and
diagnosis, and therapeutic drug treatment of cancer cachexia. This article reviews the research progress of
cancer cachexia based on these contexts. |
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