| Ting Zhou,Shiying Yu. Advances in the diagnosis and treatment of patients. Oncol Transl Med, 2018, 4: 133-143. |
| 肿瘤患者合并恶病质的诊治进展 |
| Advances in the diagnosis and treatment of patients |
| Received:June 08, 2018 Revised:August 27, 2018 |
| DOI：10.1007/s10330-018-0279-9 |
| 中文关键词: 恶病质,恶性肿瘤,分子机制,分期诊断,治疗 |
| 英文关键词: cachexia; malignant tumor; molecular mechanism; staging and diagnosis; treatment |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Ting Zhou | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | 446545093@qq.com | | Shiying Yu* | Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | syyu@tjh.tjmu.edu.cn |
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| 中文摘要: |
| 恶病质是肿瘤患者常见的并发症,发生率在50%以上,可导致20%的肿瘤患者死亡。恶病质可显著降低肿瘤患者的抗肿瘤治疗疗效,增加治疗毒副反应,加重患者的症状负担,影响患者的生活质量,并最终缩短患者的生存时间。恶病质的发生机制复杂多样,多种因子及通路在其中扮演了重要作用,而恶病质的治疗也包括营养支持治疗、促食欲药物、针对发生机制的特异性药物干预等多模式处理。近年来,随着对恶病质认识的逐渐加深,肿瘤恶病质在分子机制、分期诊断及药物治疗等方面都有了显著进展,本文将从以上几方面对肿瘤恶病质的研究进展进行综述。 |
| 英文摘要: |
| Cachexia is a common complication with an incidence rate of 50%–80% in cancer patients. It is also
responsible for 20% of mortality among these patients. Cachexia can significantly reduce the efficacy of
antitumor therapies and increase treatment-related toxicity and adverse effects in cancer patients. This
increases the symptom burden in patients, affects their quality of life, and ultimately shortens their survival
time. The mechanism underlying the development of cachexia is complex and diverse and involves various
factors and pathways, each playing an important role. Treatment approaches for cachexia are multimodal,
including nutrition support therapy, appetite stimulants, and therapeutic drugs that specifically target
the mechanism behind the disease. In recent years, we have gradually gained a better understanding
of cachexia, and significant progress has been made in delineating molecular mechanisms, staging and
diagnosis, and therapeutic drug treatment of cancer cachexia. This article reviews the research progress of
cancer cachexia based on these contexts. |
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