| Cheng Yang,Jun Peng,Xingfeng Ren. Protective effects of probucol in rats with postoperative acute renal failure. Oncol Transl Med, 2018, 4: 62-67. |
| 普罗布考对术后急性肾功能衰竭大鼠的保护作用 |
| Protective effects of probucol in rats with postoperative acute renal failure |
| Received:March 30, 2018 Revised:May 14, 2018 |
| DOI：10.1007/s10330-018-0264-4 |
| 中文关键词: 普罗布考；缺血-再灌注；肾脏；氧化应激 |
| 英文关键词: probucol; ischemia-reperfusion; acute renal failure; oxidative stress |
| 基金项目:湖北省卫生计生委科研课题项目，项目编号：WJ2015Z042 |
| Author Name | Affiliation | E-mail | | Cheng Yang* | Department of Nephrology, Wuhan General Hospital of PLA | xxjjyycc@sina.com | | Jun Peng | Department of Nephrology, Wuhan General Hospital of PLA | | | Xingfeng Ren | 解放军武汉总医院肾病内科 武汉430070 | |
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| 中文摘要: |
| 目的：探讨普罗布考对肾脏缺血-再灌注损伤(ischemia reperfusion injury,IRI)导致急性肾功能衰竭的大鼠保护性作用。方法：雄性SD大鼠40只,随机分为假手术组(S组)、缺血-再灌注组(Ischemia reperfusion．IR组)、普罗布考低剂量治疗组(Probucol+IR1组, P+IR1组；普罗布考250mg/(kg.d)灌胃)、普罗布考高剂量治疗组(P+IR2组；普罗布考500mg/(kg.d)灌胃)。S组和IR组大鼠每天温开水灌胃。1周后制备肾IRI大鼠模型；模型制备后再喂食1周,留取血、尿及肾组织标本；检测大鼠各种生化指标,血清和肾组织中超氧化物歧化酶(SOD)和丙二醛(MDA),观察肾组织病理学改变。结果：P+IR1组和P+IR2组24h尿蛋白排泄量、尿NAG酶、CysC、BUN、Cr明显低于IR组(P<0.05),血清和肾组织中SOD明显上升、MDA明显下降(P<0.05),肾组织病理损伤减轻,肾指数明显改善(P<0.05)。结论：普罗布考对急性肾功能衰竭大鼠的肾功能,有减轻和治疗作用。 |
| 英文摘要: |
| Objective?We investigated the protective effect of probucol in rats with acute renal failure caused by various ischemia-reperfusion injuries (IRIs) after surgery.
Methods?Forty male Sprague-Dawley rats were randomly divided into a sham operation group (S group), ischemia reperfusion group (IR group), probucol low-dose treatment group (probucol IR group 1, P IR 1 group; probucol 250 mg/kg intragastric administration daily), and probucol high-dose treatment group (P IR 2 group; probucol 500 mg/kg intragastric administration daily). Rats in the S and IR groups were intragastrically administered with warm water every day. After 1 week, the kidney IRI rat models were prepared, after which the rats were fed for another week, and blood, urine, and the kidney tissue specimens were retained. A series of biochemical indices, superoxide dismutase (SOD), and malondialdehyde in the serum and kidney tissues were detected, and pathological changes in renal tissue were observed.
Results?Twenty-four-hour urinary protein excretion, urinary NAGase, CysC, blood urea nitrogen (BUN), and creatinine were significantly lower in the P IR 1 and P IR 2 groups than in the IR group (P < 0.05). Superoxide dismutase in the serum and renal tissue increased significantly, malondialdehyde decreased significantly (P < 0.05), renal pathological injury was alleviated, and the kidney index improved significantly (P < 0.05).
Conclusion?Probucol can relieve various types of acute renal failure in postoperative rats.
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