| Huang Tingting,Qiu Hong,Yuan Xianglin. Targeted therapy of gastric cancer: current and prospective strategies. Oncol Transl Med, 2018, 4: 41-47. |
| 胃癌靶向治疗：现状及未来 |
| Targeted therapy of gastric cancer: current and prospective strategies |
| Received:March 30, 2018 Revised:May 17, 2018 |
| DOI：10.1007/s10330-018-0263-3 |
| 中文关键词: 胃癌；靶向治疗 |
| 英文关键词: gastric cancer; targeted therapy; clinical trials |
| 基金项目:]国家自然科学基金资助项目(No.81372664) |
| Author Name | Affiliation | E-mail | | Huang Tingting | Department of Oncology,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | huangttcx@163.com | | Qiu Hong | Department of Oncology,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Yuan Xianglin* | Department of Oncology,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | xlyuan1020@163.com |
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| 中文摘要: |
| 胃癌是全世界死亡率排名第三的恶性肿瘤。手术是唯一的根治性方法。化疗在晚期胃癌患者中的作用有限,中位OS不足1年。因此,寻找新的治疗策略极为迫切。目前胃癌中只批准了曲妥珠单抗和雷莫芦单抗两种靶向药物,绝大多数靶向药物在胃癌III期临床试验中均失败了。本文追溯了胃癌靶向治疗药物的相关研究进展,讨论了相关药物临床试验失败的原因,为胃癌的靶向治疗指明新的方向。 |
| 英文摘要: |
| Gastric cancer is the third leading cause of cancer-related death worldwide. Surgery is currently the only curative treatment strategy. Chemotherapy has shown limited efficacy in advanced gastric cancer patients with a median overall survival of less than one year. Thus, new treatments are urgently needed. Trastuzumab and Ramucirumab are the only targeted therapies approved currently. Most Phase III clinical trials evaluating targeted drugs in gastric cancer have failed. This review will evaluate relevant clinical trials with targeted therapies performed in gastric cancer patients, discuss the possible reasons for the failure, and indicate new possibilities to enhance gastric cancer treatment.
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