| Shunfang Liu,Ping Peng,Wei Sun,Dongbo Liu. Nutritional status changes in patients with advanced non-small cell lung cancer receiving first-line chemotherapy. Oncol Transl Med, 2018, 4: 54-57. |
| 晚期非小细胞肺癌患者一线化疗期间的营养状态变化 |
| Nutritional status changes in patients with advanced non-small cell lung cancer receiving first-line chemotherapy |
| Received:March 26, 2018 Revised:May 19, 2018 |
| DOI：10.1007/s10330-018-0262-2 |
| 中文关键词: 肺癌；胃肠道症状；体重下降；化疗；血红蛋白；白蛋白 |
| 英文关键词: lung cancer; gastrointestinal symptoms; weight loss; chemotherapy; hemoglobin; albumin |
| 基金项目: |
| Author Name | Affiliation | Department | | Shunfang Liu | Cancer Center,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Cancer Center | | Ping Peng | Cancer Center,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Cancer Center | | Wei Sun | Cancer Center,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Cancer Center | | Dongbo Liu* | Cancer Center,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | Cancer Center |
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| 中文摘要: |
| 目的：评估晚期非小细胞肺癌患者接受一线化疗期间的营养状态变化。
方法：共有104例接受一线化疗的晚期非小细胞肺癌患者纳入本项研究。记录患者体重变化、BMI变化和化疗期间的胃肠道症状。统计分析对比患者两周期化疗前后的体重、BMI、血红蛋白和白蛋白变化。
结果：在接受治疗前6个月，65.38%（68/104）的患者在化疗前出现了体重下降，其中30.77%的患者出现了≥5%的体重下降，12.5%的患者出现了≥10%的体重下降。48.08% (50/104)的患者在接受2周期化疗后出现了体重下降。患者2周期化疗后的体重为61.47 ± 10.37 Kg，与化疗前相比显著下降（P<0.05）。患者2周期化疗后的BMI胃22.66 ± 3.34 kg/m2，与化疗前相比显著下降（P<0.05）。化疗期间患者最常出现的胃肠道症状依次为食欲下降(80/104, 76.92%), 恶心 (53/104, 50.96%), 便秘(49/104, 47.12%), 呕吐 (48/104, 46.15%), 味觉异常 (40/104, 38.46%), 早饱 (32/104, 30.77%)。化疗后患者血红蛋白为117.06 ± 16.67 g/L，与化疗前相比显著下降 (P<0.05)。患者白蛋白水平在化疗前后无明显统计学差异（38.29 ± 4.22 g/L vs. 38.17 ± 4.54 g/L, P=0.798）
结论：化疗期间的体重下降，胃肠道症状和血红蛋白下降是决定晚期非小细胞肺癌患者一线化疗期间营养状态的重要因素，应该纳入临床治疗中的筛查、评估和干预。 |
| 英文摘要: |
| Objective?This study aimed to assess the real-life nutritional status changes and gastrointestinal symptoms in patients with advanced non-small cell lung cancer (NSCLC) receiving chemotherapy.
Methods?A total of 104 patients with metastatic NSCLC receiving first-line chemotherapy were included in this study. Unintentional weight loss, body mass index (BMI) changes, and gastrointestinal symptoms were recorded and evaluated. Biochemical parameters [hemoglobin (Hb) and albumin levels] were compared before and after two chemotherapy cycles using SPSS software.
Results?Of these patients, 65.38% (68/104) experienced unintentional weight loss, whereas 30.77% and 12.5% presented with ≥ 5% and ≥ 10% degrees of weight loss, respectively, within 6 months before first-line chemotherapy was administered. Then, 48.08% (50/104) of the patients experienced unintentional weight loss after two chemotherapy cycles. The mean body weight after chemotherapy was 61.47 ± 10.37 kg, which was significantly decreased relative to that before chemotherapy (P < 0.05). The mean BMI after chemotherapy was 22.66 ± 3.34 kg/m2, which was also significantly diminished with respect to that during the previous chemotherapy cycle (P < 0.05). The most common gastrointestinal symptoms reported among all the study patients were anorexia (80/104, 76.92%), nausea (53/104, 50.96%), constipation (49/104, 47.12%), vomiting (48/104, 46.15%), taste disorders (40/104, 38.46%), and early satiety (32/104, 30.77%). The mean Hb levels after chemotherapy were 117.06 ± 16.67 g/L, which were significantly lower than those before chemotherapy (132.73 ± 16.42 g/L) (P < 0.05). No significant difference was noted between the mean albumin levels before and after chemotherapy (38.29 ± 4.22 g/L vs 38.17 ± 4.54 g/L; P = 0.798).
Conclusion?Weight loss history, gastrointestinal symptoms, and Hb level decreases are determinant factors of nutritional status in patients with advanced NSCLC and must be included in the screening, evaluation, and treatment of lung carcinoma.
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