| Yunsheng Wang,Qinjiang Liu,Youxin Tian. Correlation between sodium-iodide symporter expression and circulating tumor cell positivity in differentiated thyroid carcinoma. Oncol Transl Med, 2018, 4: 68-71. |
| 分化型甲状腺癌组织NIS表达与循环肿瘤细胞的相关性 |
| Correlation between sodium-iodide symporter expression and circulating tumor cell positivity in differentiated thyroid carcinoma |
| Received:March 18, 2018 Revised:May 19, 2018 |
| DOI：10.1007/s10330-018-0260-0 |
| 中文关键词: 分化型甲状腺癌； 钠/碘同向转运体； 循环肿瘤细胞； 流式细胞术 |
| 英文关键词: differentiated thyroid cancer (DTC); sodium-iodide symporter (NIS); circulating tumor cell flow cytometry |
| 基金项目:甘肃省重点中医药项目 （GZK-2010-Z9） |
| Author Name | Affiliation | E-mail | | Yunsheng Wang | Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province | wangys208@foxmail.com | | Qinjiang Liu* | Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province | LIUQJ99@126.com | | Youxin Tian | Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province | |
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| 中文摘要: |
| 目的 探讨分化型甲状腺癌钠/碘同向转运体（sodium/iodide symporter，NIS）与外周血循环肿瘤细胞（Circulating Tumor Cell, CTC）的相关性。方法 收集分化型甲状腺癌172例，通过免疫组织化学S-P法及流式细胞术，对甲状腺癌组织NIS表达及外周血CTC阳性率进行检测分析。结果 分化型甲状腺癌组织NIS表达76例（44.2%），外周血CTC阳性63例（36.6%）。淋巴结N0与N1组NIS表达差异有显著性（χ2=6.015，P=0.014）、CTC阳性率差异有显著性（χ2=14.035，P=0.001）。在N0组及N1组中NIS表达与CTC阳性率，均呈显著性负相关（r=-0.383、-0.610, P=0.002、＜0.001）；各病理亚型之间NIS表达差异有显著性（χ2 =7.897，P=0.005）、CTC阳性率差异无统计学意义（χ2=1.455，P=0.228）。高分化型及中间分化型中NIS表达与CTC阳性率，均呈显著性负相关（r=-0.591、-0.443, P＜0.001、P=0.002）。结论 分化型甲状腺癌组织NIS表达与外周血CTC阳性率呈显著性负相关，其恶性程度、 淋巴结转移与NIS表达呈负相关，与CTC阳性率呈正相关。 |
| 英文摘要: |
| Objective?We investigated the correlation between the expression of the sodium-iodide symporter (NIS) and the detection of circulating tumor cells (CTCs) in differentiated thyroid carcinoma (DTC).
Methods?NIS expression in differentiated thyroid and the positive rate of CTCs in the peripheral blood were determined by immunohistochemistry S-P and flow cytometry from the records of 172 cases of differentiated thyroid carcinoma.
Results?Seventy-six cases (44.2%) expressed NIS in the differentiated thyroid and 63 cases (36.6%) were positive for CTCs in the peripheral blood. There was a significant difference between N0 and N1 in the expression of NIS (χ2 = 6.015, P = 0.014) and the positive rate of CTCs (χ2 = 14.035, P = 0.001). N0 and N1 also differed significantly in the expression of NIS (r = -0.383, -0.610, P = 0.002, < 0.001). The differences in the NIS expression, but not in the positive rate of CTCs, were significant among the different pathological subtypes (χ2 = 7.897, P = 0.005; χ2 = 1.455, P = 0.228, respectively). There was a significant negative correlation between the highly differentiated type and intermediate differentiation type both in the expression of NIS and positive rate of CTCs (r = -0.591, -0.443, P < 0.001, P = 0.002).
Conclusion?There was a significant negative correlation between the expression of tissue NIS and positive rate of CTCs in the peripheral blood in DTC. The malignancy level and lymph node metastasis in differentiated thyroid carcinoma were negatively correlated with NIS expression and positively correlated with the positive rate of CTC.
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