| Wei Luan,Wen-Xin Li. Safety and efficacy of multi-kinase inhibitor plus endostar treatment in patients with metastatic renal cell carcinoma and pleural effusion. Oncol Transl Med, 2018, 4: 10-12. |
| 多激酶抑制剂联合恩度胸腔注射治疗晚期肾癌患者合并胸腔积液的临床分析 |
| Safety and efficacy of multi-kinase inhibitor plus endostar treatment in patients with metastatic renal cell carcinoma and pleural effusion |
| Received:January 07, 2018 Revised:March 29, 2018 |
| DOI：10.1007/s10330-017-0250-0 |
| 中文关键词: 肾细胞癌；胸腔积液；多激酶抑制剂；恩度 |
| 英文关键词: renal cell carcinoma; pleural effusion; multi-kinase inhibitor; endostar |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Wei Luan | Departments of Oncology,Inner Mongolia people's Hospital | luan1977@126.com | | Wen-Xin Li* | Departments of Oncology,Inner Mongolia people's Hospital | liwenxin1888@sohu.com |
|
| Hits: 9219 |
| Download times: 11346 |
| 中文摘要: |
| 摘要 目的 评价多激酶抑制剂联合恩度胸腔注射治疗晚期肾癌患者伴胸腔积液的有效率和不良反应。方法 选择2014年1月至2015年10月晚期肾癌(透明细胞癌8例，乳头状癌1例，嫌色细胞癌1例)合并胸腔积液患者10例，其中，使用索拉菲尼4例（索拉菲尼400mg，2次/d，口服），舒尼替尼6例（舒尼替尼50mg、1次/d，口服，服药2周，停药1周）。口服多激酶抑制剂同时以恩度15mg/d1-4胸腔注射，7天为1周期，治疗1-2周期。结果 恩度胸腔注射有效率70%，不良反应轻微。结论 多激酶抑制剂联合恩度胸腔注射控制肾癌伴发的胸腔积液安全有效。 |
| 英文摘要: |
| Objective The aim of this study was to evaluate the safety and efficacy of multi-kinase inhibitor plus
endostar treatment in patients with metastatic renal cell carcinoma (mRCC) and pleural effusion.
Methods A total of 10 patients with mRCC (8 clear-cell RCCs, 1 papillary RCC, 1 chromophobe RCC)
with pleural effusion from January 2014 to October 2015 were recruited. Four patients received sorafenib
(400 mg, twice daily), while six received sunitinib (50 mg, once daily; 2 weeks on and 1 week off). All
patients received multi-kinase inhibitor plus pleural cavity perfusion of endostar (15 mg on days 1–4 for 1
or 2 weeks).
Results The response rate of pleural effusion was 70%. Adverse reactions were limited and mild.
Conclusion The regimen of multi-kinase inhibitor plus pleural cavity perfusion of endostar was both
effective and safe for the treatment of patients with mRCC with pleural effusion, and may control local
symptoms. |
|
View Full Text
Download reader HTML全文 |
| Close |