| Ying Li,Xiao Juan Yang,Zhan Zhan Zhang,Xiao Ning Kang,Shang Long Liu. Accuracy of preoperative serum CA19-9 levels in predicting the resectability of patients with pancreatic adenocarcinoma. Oncol Transl Med, 2018, 4: 6-9. |
| CA19-9水平预测胰腺癌可切除性研究 |
| Accuracy of preoperative serum CA19-9 levels in predicting the resectability of patients with pancreatic adenocarcinoma |
| Received:January 04, 2018 Revised:March 23, 2018 |
| DOI：10.1007/s10330-018-0249-9 |
| 中文关键词: 胰腺癌；CA19-9；可切除性 |
| 英文关键词: pancreatic adenocarcinoma; CA19-9; resectability |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Ying Li | Affiliated Hospital of Medical College，Qingdao University, 16 Jiangsu Road, Qingdao 266003, P. R. China | ly2016qyfy@163.com | | Xiao Juan Yang | Affiliated Hospital of Medical College,Qingdao University, Jiangsu Road
P R China | | | Zhan Zhan Zhang | Department of Nephropathy，Tengzhou Hospital of Traditional Chinese Medicine，Shandong Provence | | | Xiao Ning Kang | Affiliated Hospital of Medical College，Qingdao University, 16 Jiangsu Road, Qingdao 266003, P. R. China | | | Shang Long Liu* | Department of General Surgery, Affiliated Hospital of Medical College，Qingdao University, 16 Jiangsu Road, Qingdao 266003, P. R. China | liushanglong-1@163.com |
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| 中文摘要: |
| 目的：评估CA19-9水平预测胰腺癌可切除的正确性
方法：检测经穿刺证实胰腺癌患者术前血CA19-9水平。受试者工作曲线方法评估CA19-9最佳临界值。根据此临界值计算敏感性、特异性、阳性预测值、阴性预测值。
结果：纳入76例胰腺癌患者经术前影像学评估具有潜在可切除性。44例患者接受了根治性手术。不可切除患者术前CA19-9水平高于可切除患者组(P=0.0036)。受试者工作面积是0.749 (95% CI: 0.637-0.842)。当CA19-9临界值定于359.1 U/ml是，其敏感性、特异性、阳性预测值、阴性预测值分别是71.9% (95% CI: 53.3%-86.3); 70.5% (95% CI: 54.8%-83.2%); 63.9% (95% CI: 46.0%-79.4%); 77.5% (95% CI: 61.5%-89.2%)。
结论：术前CA19-9水平对预测胰腺癌可切除是一个有价值指标之一。 |
| 英文摘要: |
| Objective To assess the accuracy of preoperative serum CA19-9 levels in predicting the resectability of
pancreatic adenocarcinoma.
Methods Patients with biopsy-proven pancreatic adenocarcinoma who had preoperative serum CA19-9
level data were enrolled in the present retrospective analysis. Receiver operating characteristics (ROC)
curve analysis was used to determine the optimal cut-off value of CA19-9. The sensitivity, specificity,
positive predictive value, and negative predictive value were calculated at this cut-off point.
Results Seventy-six patients with pancreatic adenocarcinoma that was considered potentially resectable
according to radiological imaging were included. Of all 76 patients, 44 received complete resection of
the pancreatic adenocarcinoma. The preoperative serum CA19-9 level was significantly higher in the
unresectable tumor group than in the resectable tumor group (P = 0.0036). The area under the ROC
curve was 0.749 (95% confidence interval [CI]: 0.637–0.842). When the cut-off value of CA19-9 was set
to 359.1 U/mL, the sensitivity, specificity, positive and negative predictive values were 71.9% (95% CI:
53.3%–86.3%), 70.5% (95% CI: 54.8%–83.2%), 63.9% (95% CI: 46.0%–79.4%), and 77.5% (95% CI:
61.5%–89.2%), respectively.
Conclusion The preoperative serum CA19-9 level is useful for predicting the resectability of pancreatic
adenocarcinoma. |
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