| Xin Cui,Caixin Zhang,Yunhui Li,Yongyun Qi,Xiaoyan Ding,Shumin Hei,Weiqing Huang. Function and clinical significance of SUMOylation in type I endometrial carcinoma. Oncol Transl Med, 2017, 3: 249-253. |
| Function and clinical significance of SUMOylation in type I endometrial carcinoma |
| Received:November 27, 2017 Revised:January 01, 2018 |
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| KeyWord:SUMOylation; Ubc9; sentrin-specific peptidase 1 (SENP1); immunohistochemistry |
| Author Name | Affiliation | E-mail | | Xin Cui | Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China | 846171214@qq.com | | Caixin Zhang | Department of Pathology,Qingdao municipal hospital,Shandong QingdaoS China | | | Yunhui Li | Department of Obstetrics and Gynecology,affiliated medical college of Qingdao University | | | Yongyun Qi | Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China | | | Xiaoyan Ding | Department of Pathology,affiliated medical college of Qingdao University,Shandong QingdaoS China | | | Shumin Hei | Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China | | | Weiqing Huang | Department of Pathology,Qingdao municipal hospital,Shandong QingdaoS China | |
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| Abstract: |
| Objective This study elucidated the function and role of SUMOylation in type I endometrial carcinoma.
Methods Fifty type I endometrial carcinoma cases and para-cancer tissue samples were collected. The
expression levels of ubiquitin-conjugating enzyme E2 I (Ube2i, Ubc9) and small ubiquitin-like modifier 1
(SUMO1)/sentrin-specific peptidase 1 (SENP1) proteins were examined using immunohistochemistry and
the correlation with clinicopathological parameters was analyzed.
Results Ubc9 expression in type I endometrial carcinoma tissues was significantly higher than that in the
para-cancer tissues; in contrast, the expression of the SENP1 protein was markedly lower than that in the
para-cancer tissues. Ubc9 and SENP1 expression levels were negatively correlated and were associated
with tumor differentiation, but not age, depth of invasion, tumor stage, and lymph node metastasis.
Conclusion SUMOylation modification plays a major role in the pathogenesis and development of
type I endometrial carcinoma. Thus, it could be a potential target for the treatment of endometrial cancer. |
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