| Xin Cui,Caixin Zhang,Yunhui Li,Yongyun Qi,Xiaoyan Ding,Shumin Hei,Weiqing Huang. Function and clinical significance of SUMOylation in type I endometrial carcinoma. Oncol Transl Med, 2017, 3: 249-253. |
| SUMO化修饰在I 型子宫内膜癌组织中的表达及其临床意义 |
| Function and clinical significance of SUMOylation in type I endometrial carcinoma |
| Received:November 27, 2017 Revised:January 01, 2018 |
| DOI：10.1007/s10330-017-0245-5 |
| 中文关键词: SUMO化修饰；Ubc9；SENP1;免疫组化 |
| 英文关键词: SUMOylation; Ubc9; sentrin-specific peptidase 1 (SENP1); immunohistochemistry |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xin Cui* | Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China | 846171214@qq.com | | Caixin Zhang | Department of Pathology,Qingdao municipal hospital,Shandong QingdaoS China | | | Yunhui Li | Department of Obstetrics and Gynecology,affiliated medical college of Qingdao University | | | Yongyun Qi | Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China | | | Xiaoyan Ding | Department of Pathology,affiliated medical college of Qingdao University,Shandong QingdaoS China | | | Shumin Hei | Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China | | | Weiqing Huang | Department of Pathology,Qingdao municipal hospital,Shandong QingdaoS China | |
|
| Hits: 9800 |
| Download times: 11272 |
| 中文摘要: |
| 目的:探讨SUMO化修饰在I型子宫内膜癌中的表达及其临床意义。方法:收集I型子宫内膜癌组织及其配对癌旁正常组织各50例，采用免疫组化法检测Ubc9和 SENP1蛋白的表达，并分析其表达与患者临床病理参数的关系。结果:1.I型子宫内膜癌组织中Ubc9蛋白的表达明显高于癌旁组织。2.I型子宫内膜癌组织中SENP1蛋白的表达明显低于癌旁组织。3.Ubc9和SENP1的阳性表达均与肿瘤的分化程度有关，而与患者的年龄、肿瘤浸润的深度、肿瘤分期及淋巴结转移无关。4. Ubc9 阳性表达与SENP1阳性表达呈负相关。结论:SUMO化修饰在I型子宫内膜癌的发生、发展中发挥着重要作用，有望成为治疗子宫内膜癌的新靶点。 |
| 英文摘要: |
| Objective This study elucidated the function and role of SUMOylation in type I endometrial carcinoma.
Methods Fifty type I endometrial carcinoma cases and para-cancer tissue samples were collected. The
expression levels of ubiquitin-conjugating enzyme E2 I (Ube2i, Ubc9) and small ubiquitin-like modifier 1
(SUMO1)/sentrin-specific peptidase 1 (SENP1) proteins were examined using immunohistochemistry and
the correlation with clinicopathological parameters was analyzed.
Results Ubc9 expression in type I endometrial carcinoma tissues was significantly higher than that in the
para-cancer tissues; in contrast, the expression of the SENP1 protein was markedly lower than that in the
para-cancer tissues. Ubc9 and SENP1 expression levels were negatively correlated and were associated
with tumor differentiation, but not age, depth of invasion, tumor stage, and lymph node metastasis.
Conclusion SUMOylation modification plays a major role in the pathogenesis and development of
type I endometrial carcinoma. Thus, it could be a potential target for the treatment of endometrial cancer. |
|
View Full Text
Download reader HTML全文 |
| Close |
|
|
|