| Li Ge,Hongwen Yao,Rong Zhang,Xiaoguang Li,Ling-Ying Wu. Papillary serous carcinoma of the uterine cervix: a clinicopathological analysis of 4 cases and a literature review. Oncol Transl Med, 2017, 3: 197-202. |
| 子宫颈乳头状浆液性腺癌：4例临床病例病理以后分析以及文献回顾 |
| Papillary serous carcinoma of the uterine cervix: a clinicopathological analysis of 4 cases and a literature review |
| Received:June 17, 2017 Revised:November 07, 2017 |
| DOI：10.1007/s10330-017-0233-3 |
| 中文关键词: 子宫颈乳头状浆液性腺癌，临床病理特征，预后分析 |
| 英文关键词: papillary serous carcinoma of uterine cervix (PSCC); clinicopathological features; prognosis analysis |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Li Ge | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | slwlaura@126.com | | Hongwen Yao | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Rong Zhang | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Xiaoguang Li | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Ling-Ying Wu* | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | wulingying@csco.org.cn |
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| 中文摘要: |
| 目的: 明确子宫颈乳头状浆液性腺癌的临床病理特征以及治疗结局。
方法:我们回顾性分析了1999年1月至2016年12月之间就诊于中国医学科学院肿瘤医院的病人，诊断为乳头状浆液性腺癌共7例，其中3例随访时间较短，未进行进一步分析。病人诊断、复发以及随访期间的检查手段包括液基细胞学检查，HPV检测，肿瘤标记物检查，活检病理以及相关的影像学检查。
结果:
4例病人的临床分期分别为IB1，IB1, IIA, IIIB。4例病人当中，有2例初始治疗之后18个月之内出现复发，我们观察到较单纯化疗的病人（11月），接受放化疗的病人无进展生存期更长(20月, 21月, 13月)，因病例数目有限，无法进行有效的统计学分析。截止到随访时间，病人的5年生存率为0%，3年生存率为75%。我们对已发表的子宫颈乳头状浆液性腺癌进行了文献回顾分析，提示早期子宫颈乳头状浆液性腺癌伴随中危或者高危因素的比例高于同期别的子宫颈普通腺癌以及鳞癌。
结论：
作为一种罕见的子宫颈腺癌亚型，乳头状浆液性腺癌的临床预后差，较术后单一的化疗，放化疗结合显示了在无进展生存时间延长方面的获益趋势。 |
| 英文摘要: |
| Objective To investigate the clinicopathological characteristics and clinical treatment outcomes of
patients with papillary serous carcinoma of the uterine cervix (PSCC).
Methods In this study, 4 patients with histologically confirmed papillary serous carcinoma of the uterine
cervix were retrospectively investigated. Pap smears, human papillomavirus (HPV) screening, tumor
marker status, biopsy analysis, and relevant imaging examinations were conducted for the confirmation of
primary diagnosis and recurrence. Patients underwent surgery, chemotherapy, or radiotherapy, and survival
were the main endpoint.
Results The 4 patients were diagnosed with IB1, IB1, IIA, or IIIB disease. Two patients (2/4) presented
with recurrence within 18 months after primary therapy. Compared with chemotherapy alone (progressionfree
survival (PFS): 11 months), radiotherapy combined with adjuvant chemotherapy showed favorable
PFS rates (PFS: 20, 36, 13 months in 3 cases), although valid statistical analysis was not feasible because
of the small sample size. The 5-year survival rate was 0%, and the 3-year survival rate was 75%. Our data,
in agreement with the literature evidence, showed that the number of moderate-risk and high-risk factors in
patients diagnosed with PSCC at an early stage was higher than that in patients diagnosed with common
adenocarcinoma/squamous carcinoma of the uterine cervix.
Conclusion PSCC has a poor clinical prognosis, and compared with chemotherapy alone, radiotherapy
combined with adjuvant chemotherapy may lead to improved PFS. |
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