| Renyi Qin,Chunyang Ma,Xunjun Guo,Feng Zhu,Yuqi Ren,Hebin Wang,Min Wang. Retroperitoneal hyaline-vascular variant Castleman Disease in a patient with iron-deficiency anemia and sinus bradycardia: a case report. Oncol Transl Med, 2017, 3: 176-180. |
| 合并缺铁性贫血和窦性心动过缓的一例腹膜后透明血管型Castleman病-----病例报告 |
| Retroperitoneal hyaline-vascular variant Castleman Disease in a patient with iron-deficiency anemia and sinus bradycardia: a case report |
| Received:June 01, 2017 Revised:July 25, 2017 |
| DOI：10.1007/s10330-016-0232-2 |
| 中文关键词: Castleman病，窦性心动过缓，缺铁性贫血 |
| 英文关键词: Castleman disease; sinus bradycardia; iron-deficiency anemia |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Renyi Qin* | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | ryqin@tjh.tjmu.edu.cn | | Chunyang Ma | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Xunjun Guo | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Feng Zhu | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Yuqi Ren | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Hebin Wang | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Min Wang | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | |
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| 中文摘要: |
| Castleman病，也称为巨大淋巴结增生症，病变通常发生于淋巴结胸部淋巴结，最常见于纵隔淋巴结。窦性心动过缓是指频率小于每分钟60次的窦性心律。窦性心动过缓可以是一种疾病，但也可以出现在健康人群中。但是，Castleman病合并窦性心动过缓的病例目前没有出现相关报道。现在，我们将报道一例Castleman病合并持续性窦性心动过缓和缺铁性贫血的病例。患者是一位46岁女性。辅助检查发现肝脾肿大和脾门区肿块。手术切除后，患者的心动过缓也即刻得到治愈，而在后续化疗过程中，她的贫血也得到纠正。术后病理检查显示良性病变淋巴结，患者被诊断为透明血管型Castleman病。这是第一个与Castleman病相关的窦性心动过缓的案例报道。我们描述该患者的病例特点，探讨Castleman病相关的窦性心动过缓可能的发病机制，并预测Castleman病相关的症状性窦性心动过缓伴的合理治疗方法。 |
| 英文摘要: |
| Castleman disease, also known as giant lymph node hyperplasia, involves lesions in the
lymph nodes usually located in the chest_ENREF_1, particularly in the mediastinum. Meanwhile, sinus
bradycardia is a sinus rhythm slower than 60 beats per min, and it can occur in both healthy and sick
individuals. However, the comorbidity of these two disorders has not been previously reported. In this
paper, we report a case of a 46-year-old woman who presented with persistent sinus bradycardia and irondeficiency anemia. Diagnostic work-up revealed hepatosplenomegaly and a giant mass near the splenic
hilum. The mass was removed surgically; after which, the patient’s bradycardia resolved immediately, while
her anemia was corrected after subsequent chemotherapy. Pathological examination revealed lymph nodes
with benign lesions, and the patient was diagnosed with hyaline-vascular variant of Castleman disease.
This is the first documented case of sinus bradycardia associated with Castleman disease. In this paper,
we describe the case characteristics, discuss the possible pathogenesis, and consider the appropriate
treatment of symptomatic sinus bradycardia accompanying Castleman disease. |
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