| Hanaa A. Atwa,Hanaa M. Ibrahim,Eman I.Ismail,Islam M.Ibrahim. ALDH 1A1 and caveolin-1 expression in triple negative breast cancer. Oncol Transl Med, 2017, 3: 185-196. |
| ALDH 1A1 and Caveoline 1 expression in triple negative breast cancer |
| ALDH 1A1 and caveolin-1 expression in triple negative breast cancer |
| Received:May 28, 2017 Revised:October 02, 2017 |
| DOI：10.1007/s10330-017-0231-1 |
| 中文关键词: ALDH 1A1A1, caveolin 1, TNBC, Stem;cells |
| 英文关键词: sldehyde dehydrogenase-1 (ALDH 1A1); caveolin-1 (Cav-1); triple negative breast cancer (TNBC); stem cells |
| 基金项目: |
| Author Name | Affiliation | Department | | Hanaa A. Atwa | Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | Pathology Department | | Hanaa M. Ibrahim | Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | Pathology Department | | Eman I.Ismail* | Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | Clinical Oncology and Nuclear Medicine Department | | Islam M.Ibrahim | Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | General surgery Department |
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| 中文摘要: |
| Backgrounds: Triple negative breast cancer (TNBC) contain high proportion of breast cancer stem cells (BCSCs) and exhibit resistance to chemotherapy treatments thus, identification of novel molecular targeting BCSCs may improve patient survival. Aldehyde dehydrogenase-1 (ALDH 1A1) has been considered as cancer stem cell marker in different tumors. Caveolin-(CAv-1) 1, a membrane transporter protein regulates cancer chemo-resistance and stem cell signaling.
Aim of this work was to study expression of ALDH 1A1 and Caveolin-(CAv-1)1 in TNBC patients by immunohistochemistry (IHC), correlating their expression with clinical and pathological parameters
Materials and Methods: Paraffin blocks of 30 breast cancer patients who underwent modified radical mastectomy between January 2013 and December 2016 in Zagazig University hospitals. Antibodies to ALDH 1A1 and caveolin-1(Cav-1) were used. Results: ALDH 1A1 and Caveolin-1 are significantly correlated with tumor size. A significant association between ALDH 1A1/Caveolin IHC staining and relapse was found. CAV1 and ALDH 1A1positive expression was correlated with short 3year disease free survival rate and 3year overall survival rate (p<0.001).
Conclusion: ALDH 1A1 and CAV1 expression in TNBC was signifi?cantly positively correlated with bad clinicopathological parameters, shortened survival. Expression of both markers was significantly positively correlated with each other (p<0.001). ALDH 1A1and CAV1 could be a possible therapeutic target in breast cancer. |
| 英文摘要: |
| Objective Triple negative breast cancer (TNBC) contains a high proportion of breast cancer stem cells
(BCSCs) and exhibits resistance to chemotherapy treatments. Therefore, the identification of BCSCs that
are novel molecular targets may improve patient survival. Aldehyde dehydrogenase-1 (ALDH 1A1) has
been considered a cancer stem cell marker in different tumors. Caveolin-1 (Cav-1), a membrane transporter
protein, regulates cancer chemo-resistance and stem cell signaling. Thus, the aim of this study was to
evaluate the expression of ALDH 1A1 and Cav-1 in patients with TNBC by immunohistochemistry (IHC) and
to correlate their expression with clinical and pathological parameters.
Methods Paraffin blocks of 30 breast cancer patients who underwent modified radical mastectomy
between January 2013 and December 2016 in Zagazig University Hospitals (Egypt) were evaluated.
Antibodies to ALDH 1A1 and Cav-1 were used.
Results ALDH 1A1 and Cav-1 significantly correlated with tumor size. A significant association between
ALDH 1A1/Cav-1 IHC staining and relapse was found. Cav-1 and ALDH 1A1-positive expression correlated
with a short 3-year disease-free survival rate and a 3-year overall survival rate (P < 0.001).
Conclusion ALDH 1A1 and Cav-1 expression in TNBC was significantly positively correlated with
poor clinicopathological parameters and shortened survival. Expression of both markers was significantly
positively correlated with each other (P < 0.001). ALDH 1A1 and Cav-1 could be potential therapeutic
targets in breast cancer. |
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