| Hanaa A. Atwa,Hanaa M. Ibrahim,Eman I.Ismail,Islam M.Ibrahim. ALDH 1A1 and caveolin-1 expression in triple negative breast cancer. Oncol Transl Med, 2017, 3: 185-196. |
| ALDH 1A1 and caveolin-1 expression in triple negative breast cancer |
| Received:May 28, 2017 Revised:October 02, 2017 |
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| KeyWord:sldehyde dehydrogenase-1 (ALDH 1A1); caveolin-1 (Cav-1); triple negative breast cancer (TNBC); stem cells |
| Author Name | Affiliation | Department | | Hanaa A. Atwa | Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | Pathology Department | | Hanaa M. Ibrahim | Pathology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | Pathology Department | | Eman I.Ismail | Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | Clinical Oncology and Nuclear Medicine Department | | Islam M.Ibrahim | Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | General surgery Department |
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| Abstract: |
| Objective Triple negative breast cancer (TNBC) contains a high proportion of breast cancer stem cells
(BCSCs) and exhibits resistance to chemotherapy treatments. Therefore, the identification of BCSCs that
are novel molecular targets may improve patient survival. Aldehyde dehydrogenase-1 (ALDH 1A1) has
been considered a cancer stem cell marker in different tumors. Caveolin-1 (Cav-1), a membrane transporter
protein, regulates cancer chemo-resistance and stem cell signaling. Thus, the aim of this study was to
evaluate the expression of ALDH 1A1 and Cav-1 in patients with TNBC by immunohistochemistry (IHC) and
to correlate their expression with clinical and pathological parameters.
Methods Paraffin blocks of 30 breast cancer patients who underwent modified radical mastectomy
between January 2013 and December 2016 in Zagazig University Hospitals (Egypt) were evaluated.
Antibodies to ALDH 1A1 and Cav-1 were used.
Results ALDH 1A1 and Cav-1 significantly correlated with tumor size. A significant association between
ALDH 1A1/Cav-1 IHC staining and relapse was found. Cav-1 and ALDH 1A1-positive expression correlated
with a short 3-year disease-free survival rate and a 3-year overall survival rate (P < 0.001).
Conclusion ALDH 1A1 and Cav-1 expression in TNBC was significantly positively correlated with
poor clinicopathological parameters and shortened survival. Expression of both markers was significantly
positively correlated with each other (P < 0.001). ALDH 1A1 and Cav-1 could be potential therapeutic
targets in breast cancer. |
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