| Jianfei Zhu,Jinyan Yuan,Yawei Dou,Wei Tian,Shudong Li,Hongtao Wang,Zhe Li. Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer?. Oncol Transl Med, 2017, 3: 156-159. |
| EGFR基因突变状态的检测对于吸烟的非小细胞肺癌患者是否没有必要？ |
| Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer? |
| Received:May 08, 2017 Revised:July 24, 2017 |
| DOI：10.1007/s10330-017-0228-8 |
| 中文关键词: EGFR基因 吸烟 非小细胞肺癌 相关性 |
| 英文关键词: epidermal growth factor receptor (EGFR) mutation; smoking; non-small cell lung cancer (NSCLC) |
| 基金项目: |
| Author Name | Affiliation | Department | | Jianfei Zhu | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Jinyan Yuan | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Yawei Dou | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Wei Tian | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Shudong Li | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Hongtao Wang | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Zhe Li* | Yanan University Affiliated Hospital, | Department of Thoracic Surgery |
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| 中文摘要: |
| 目的：EGFR基因突变常见于非吸烟的非小细胞肺癌患者，对于吸烟的患者，既往的研究表明吸烟量与基因的突变状态可能有关，本研究旨在研究吸烟的相关变量与EGFR基因突变状态之间的关系。方法：共计195例吸烟的非小细胞肺癌患者接受EGFR基因检测，所有标本均来自手术切除的组织标本，应用RT-PCR法对EGFR基因常见的突变位点的19外显子和21外显子进行检测。结果：本研究得出，EGFR基因在吸烟患者中的突变率为16.9%（33/195），按照吸烟指数的不同，可以将患者分为轻度吸烟，中度吸烟和重度吸烟三组，分析得出EGFR基因突变率，从轻度吸烟的38.9%降到重度吸烟的8.1%，二者呈负相关(P=0.001)。进一步分析得出，相较于每日的吸烟量(P=0.547)，初始吸烟年龄(P=0.085)和吸烟的持续年限(P=0.002)对EGFR基因的突变状态影响更大。结论：对于吸烟的非小细胞肺癌患者，仍然有将近17%的患者为突变型，吸烟指数与基因突变率呈负相关，因此，对于吸烟患者，尤其是轻度吸烟患者，进行基因检测是有临床意义的。 |
| 英文摘要: |
| Objective Previous studies have proven that cumulative smoking dose predicts the prevalence of
epidermal growth factor receptor (EGFR) mutations. The aim of this study was to investigate the relationship
between smoking-related factors and EGFR mutation status.
Methods Samples were collected from 195 smokers with non-small cell lung cancer (NSCLC) who
underwent surgical resection and the presence of EGFR mutations (exons 19 and 21) were determined by
real-time polymerase chain reaction (RT-PCR).
Results EGFR gene mutations were present in 33 (16.9%) patients who were smokers; the patients were
divided into three groups according to the smoking index (SI). The incidence of EGFR mutations decreased
from 38.9% in mild smokers to 8.1% in severe smokers (P = 0.001). Compared to daily smoking dose (P
= 0.547), initial smoking age (P = 0.085) and duration of smoking history had a larger effect on EGFR
mutation status (P = 0.002).
Conclusion Although there is a decrease in the incidence of mutations with increasing SI, there were still
around 17% of smokers with NSCLC that harbored EGFR mutations, so it is necessary to test for EGFR
mutation status in smokers with NSCLC. |
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