| Jianfei Zhu,Jinyan Yuan,Yawei Dou,Wei Tian,Shudong Li,Hongtao Wang,Zhe Li. Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer?. Oncol Transl Med, 2017, 3: 156-159. |
| Is EGFR gene mutation testing necessary in smokers with non-small cell lung cancer? |
| Received:May 08, 2017 Revised:July 24, 2017 |
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| KeyWord:epidermal growth factor receptor (EGFR) mutation; smoking; non-small cell lung cancer (NSCLC) |
| Author Name | Affiliation | Department | | Jianfei Zhu | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Jinyan Yuan | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Yawei Dou | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Wei Tian | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Shudong Li | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Hongtao Wang | Shannxi Provincial Peoples’ Hospital | Department of Thoracic Surgery | | Zhe Li | Yanan University Affiliated Hospital, | Department of Thoracic Surgery |
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| Abstract: |
| Objective Previous studies have proven that cumulative smoking dose predicts the prevalence of
epidermal growth factor receptor (EGFR) mutations. The aim of this study was to investigate the relationship
between smoking-related factors and EGFR mutation status.
Methods Samples were collected from 195 smokers with non-small cell lung cancer (NSCLC) who
underwent surgical resection and the presence of EGFR mutations (exons 19 and 21) were determined by
real-time polymerase chain reaction (RT-PCR).
Results EGFR gene mutations were present in 33 (16.9%) patients who were smokers; the patients were
divided into three groups according to the smoking index (SI). The incidence of EGFR mutations decreased
from 38.9% in mild smokers to 8.1% in severe smokers (P = 0.001). Compared to daily smoking dose (P
= 0.547), initial smoking age (P = 0.085) and duration of smoking history had a larger effect on EGFR
mutation status (P = 0.002).
Conclusion Although there is a decrease in the incidence of mutations with increasing SI, there were still
around 17% of smokers with NSCLC that harbored EGFR mutations, so it is necessary to test for EGFR
mutation status in smokers with NSCLC. |
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