| Kihn-Alarcón, Alba de Jesús,Xu Ximing. Mechanisms of radioresistance in hepatocellular carcinoma. Oncol Transl Med, 2017, 3: 165-170. |
| Mechanisms of radioresistance in hepatocellular carcinoma |
| Received:February 14, 2017 Revised:August 20, 2017 |
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| KeyWord:hepatocellular carcinoma; liver cancer; radiotherapy; radiation therapy; radioresistance |
| Author Name | Affiliation | E-mail | | Kihn-Alarcón, Alba de Jesús | Cancer Center, Renmin Hospital of Wuhan University | albaj.kihn@gmail.com | | Xu Ximing | Cancer Center, Renmin Hospital of Wuhan University. | doctorxu120@aliyun.com |
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| Abstract: |
| Hepatocellular carcinoma (HCC), one of the most common cancers in the world, is characterized by poor
prognosis and recurrence after resection. Its prevalence is highest in developing countries, particularly where
there is high incidence of hepatitis B virus infection. Several curative treatments are available for early stage
HCC; however, these options are not available for advanced disease. New techniques allowing the specific
delivery of high-dose radiotherapy enable their use in the treatment of HCC, which has been avoided
in the past due to low hepatic tolerance for radiation. This presents a new challenge—the development
of resistance to radiotherapy and subsequent disease recurrence. Recently, the mechanisms controlling
radioresistance have begun to be elucidated. Understanding the molecular basis of radioresistance is key
to developing new strategies with better treatment response and increased patient survival. |
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