| Guangjin Yuan,Qianwen Li,Shixian Chen,Chengwei Zheng,Jiang Tang,Jian Hu,Ximing Xu. Selective partial salivary glands sparing during intensity-modulated radiation therapy for nasopharyngeal carcinoma. Oncol Transl Med, 2017, 3: 65-70. |
| Selective partial salivary glands sparing during intensity-modulated radiation therapy for nasopharyngeal carcinoma |
| Received:January 03, 2017 Revised:April 19, 2017 |
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| KeyWord:nasopharyngeal carcinoma; intensity-modulated radiotherapy; selective partial salivary gland sparing |
| Author Name | Affiliation | E-mail | | Guangjin Yuan | Nationality Hospital of Qianjiang | yuantod@aliyun.com | | Qianwen Li | the 82nd Hospital of the Chinese People’s Liberation Army, Huai’an | | | Shixian Chen | Nationality Hospital of Qianjiang, Chongqing | | | Chengwei Zheng | Nationality Hospital of Qianjiang, Chongqing | | | Jiang Tang | the 82nd Hospital of the Chinese People’s Liberation Army, Huai’an | | | Jian Hu | Renmin Hospital of Wuhan University, Wuhan | | | Ximing Xu | Renmin Hospital of Wuhan University, Wuhan | doxtorxu120@aliyun.com |
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| Abstract: |
| Objective This study evaluated the dosimetric consequences of selective partial salivary gland sparing
during intensity-modulated radiotherapy (IMRT) for patients with nasopharyngeal carcinoma (NPC).
Methods Ten patients with NPC were enrolled in the study. Two IMRT plans were produced for each
patient: conventional (control) and partial salivary glands-sparing (treatment), with dose constraints to the
entire parotid glands or partial salivary glands (including the parotid and submandibular glands, delineated
with the adjacent distance of at least 0.5 cm between the glands and PTV, the planning target volume) in
planning, respectively. Dosimetric parameters were compared between the two plans, including the V110%,
V100%, V95% (the volume covered by more than 110%, 100%, or 95% of the prescribed dose), Dmin (the
minimum dose) of PTV, homogeneity index (HI), conformity index (CI), and the mean dose and percentage
of the volume receiving 30 Gy or more (V30) for the parotid glands and submandibular glands.
Results Treatment plans had significantly lower mean doses and V30 to both the entire parotid glands
and partial parotid glands than those in control plans. The mean doses to the partial submandibular glands
were also significantly lower in treatment plans than in control plans. The PTV coverage was comparable
between the two plans, as indicated by V100%, V95%, Dmin, CI, and HI. The doses to critical structures, including
brainstem and spinal cord, were slightly but not significantly higher in treatment plans than in control plans.
Conclusion A selective partial salivary gland-sparing approach reduces the doses to parotid and
submandibular glands during IMRT, which may decrease the risk of post-radiation xerostomia while not
compromising target dose coverage in patients with NPC. |
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