| Fuli Zhang,Yadi Wang,Weidong Xu,Huayong Jiang,Junmao Gao,Qingzhi Liu,Na Lu,Diandian Chen,Bo Yao,Jun Hou,Heliang He,Jianping Chen. Comparison of the effects of two types of multileaf collimators on tumor control probability in radiotherapy for breast cancer after conservative surgery based on the EUD model. Oncol Transl Med, 2017, 3: 77-81. |
| 基于EUD（等效均匀剂量）模型计算乳腺癌保乳术后放疗肿瘤控制概率 |
| Comparison of the effects of two types of multileaf collimators on tumor control probability in radiotherapy for breast cancer after conservative surgery based on the EUD model |
| Received:January 02, 2017 Revised:May 01, 2017 |
| DOI：10.1007/s10330-017-0218-8 |
| 中文关键词: 肿瘤控制概率; 乳腺癌; 放射生物学; 容积旋转调强放射治疗 |
| 英文关键词: tumor control probability (TCP); breast cancer; radiobiology; volumetric modulated arc therapy (VMAT) |
| 基金项目:陆军总医院创新基金(课题编号： 2015-LC-18). |
| Author Name | Affiliation | E-mail | | Fuli Zhang | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | radiozfli@163.com | | Yadi Wang* | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Weidong Xu | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Huayong Jiang | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Junmao Gao | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Qingzhi Liu | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Na Lu | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Diandian Chen | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Bo Yao | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Jun Hou | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Heliang He | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | | | Jianping Chen | Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng | |
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| 中文摘要: |
| 目的: 通过回顾性研究计算并比较基于两种类型多叶准直器（MLC）的乳腺癌保乳术后容积旋转调强放射治疗的肿瘤控制概率（TCP）。
材料和方法: 选择9例左侧乳腺癌保乳术后患者，分别基于Agility MLC 和 beam modulator (BM) MLC设计容积旋转调强放射治疗计划。处方剂量为50Gy，此处方剂量覆盖至少95%的计划靶区体积，单次实施剂量为2 Gy。依据剂量体积直方图计算肿瘤控制概率。
结果: 与基于Agility MLC的容积旋转调强放射治疗计划相比，基于BM MLC 的容积旋转调强放射治疗计划可获得较高的肿瘤控制概率(94.61% vs 94.23%)，但其治疗实施效率却比基于Agility MLC的容积旋转调强放射治疗计划低35%。
结论: 对于乳腺癌保乳术后放射治疗而言，基于BM MLC的容积旋转调强放射治疗计划可获得较高的肿瘤控制概率，而基于Agility MLC的容积旋转调强放射治疗计划实施效率更高。 |
| 英文摘要: |
| Objective To compute and compare the tumor control probability (TCP) of volumetric modulated arc
therapy (VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator
(MLC) through a retrospective planning study.
Methods For a group of 9 patients diagnosed with left breast cancer, VMAT plan based on Agility MLC
and beam modulator (BM) MLC were designed. The prescription dose was 50 Gy covering at least 95% of
the planning target volume, 2 Gy per fraction. TCPs were calculated according to dose-volume histogram
(DVH) analysis.
Results The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan (94.61% vs
94.23%) but was inferior with respect to delivery efficiency; the delivery time was reduced for Agility VMAT
plan by 35% compared to BM VMAT plan.
Conclusion For breast cancer radiation therapy after conservative surgery, BM VMAT plans provide
slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans. |
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