| KangSheng- Liu,Weimin-Fang,Er Hu-Sun,Yajun Chen. Roles of endoplasmic reticulum stress and apoptosis signaling pathways in gynecologic tumor cells: A systematic review. Oncol Transl Med, 2017, 3: 131-135. |
| 肿瘤内质网应激 |
| Roles of endoplasmic reticulum stress and apoptosis signaling pathways in gynecologic tumor cells: A systematic review |
| Received:October 23, 2016 Revised:March 24, 2017 |
| DOI：10.1007/s10330-016-0201-1 |
| 中文关键词: 肿瘤 、内质网应激、信号路径 |
| 英文关键词: endoplasmic reticulum (ER); unfolded protein response (UPR); inositol-requiring-JNK (IRE1-JNK); caspase; CCAAT-enhancer-binding protein homologous protein (CHOP); gynecologic tumor cell |
| 基金项目: |
| Author Name | Affiliation | Department | | KangSheng- Liu | Department of Clinical Laboratory, Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China | 医学诊断实验科 | | Weimin-Fang | Department of Clinical Laboratory, Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China | 医学诊断实验科 | | Er Hu-Sun | Department of Obstetrics and Gynecology, Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China | Department of Obstetrics and Gynecology | | Yajun Chen* | Department of Clinical Laboratory, Nanjing Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China | Department of Clinical Laboratory |
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| 中文摘要: |
| Endoplasmic reticulum(ER) is the largest membrane-enclosed organelle in a cell, which is responsible for the synthesis , processing and modificaton of protein. Endoplasmic reticulum is a important place of protein folding and modificating. Some studies have shown that endoplasmic reticulum stress signaling pathways involved in death process of some kinds of cells. The endoplasimc recticulum environment about oxidation and high calcium concentration is destroyed ,which will lead to the accumulation and aggregation of unfold proteins and cause severe ER stress .ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response to restore normal ER function. The full text database of pubmed and web of sci were searched, and the word” endoplasmic reticulum stress/unfolded protein response/ tumor cell apoptosis “were used as key words. To retrieve the literature about endoplasmic reticulum stress and unfolded protein response from 1998 to 2016, then 55 were used in analysis at last. These stress triggers apoptosis through a variety of signaling pathways( the activation of Chop、Ire1-1-Jnk and Caspase pathway). There is growing evidence that endoplasmic reticulum plays an important role in tumor cell diseases. The present review is discussed in the molecular mechanisms underlying UPR and able to promote survival and proliferation in tumor cell. |
| 英文摘要: |
| Efficient functioning of the endoplasmic reticulum (ER) is very important for most cellular activities, such as protein folding and modification. The ER closely interacts with other organelles, including the Golgi body, endosome, membrane, and mitochondria, providing lipids and proteins for the repair of these organelles. ER stress can be induced by various abnormal materials in the cell. ER stress is a compensatory intracellular environment disorder that occurs during areaction. ER can sense the stress and respond to it through translational attenuation, upregulation of the genes for ER chaperones and related proteins, and degradation of unfolded proteins by a quality-control system, but excessive ER activation can cause cell death. The Pubmed and Web of Science databases were searched for full-text articles, and the terms “endoplasmic reticulum stress / unfolded protein response / gynecologic tumor cell apoptosis” were used as key words. Thirty-five studies of ER stress and unfolded protein response published from 2000 to 2016 were analyzed. Stress triggers apoptosis through a variety of signaling pathways. Increasing evidence has shown that the ER plays an important role in tumor cell diseases. The present review discusses the molecular mechanisms underlying unfolded protein response and its ability to promote survival and proliferation in gynecologic tumor cells.
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