| Guozhao Meng,Junlei Yi,Ming Xie. Differential expression of nucleolin in colon adenoma and adenocarcinoma. Oncol Transl Med, 2017, 3: 82-85. |
| Differential expression of nucleolin in colon adenoma and adenocarcinoma |
| Received:October 09, 2016 Revised:April 07, 2017 |
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| KeyWord:nucleolin; colon adenoma; colon adenocarcinoma |
| Author Name | Affiliation | Department | | Guozhao Meng | School of Fundamental Medicine and Affiliated Hospital, Xiangnan University | Department of Pathology | | Junlei Yi | School of Fundamental Medicine and Affiliated Hospital, Xiangnan University | Department of Pathology | | Ming Xie | School of Fundamental Medicine and Affiliated Hospital, Xiangnan University | Department of Pathology |
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| Abstract: |
| Objective The aim of the study was to investigate the discrepancy in nucleolin expression between
colon adenoma and colon adenocarcinoma, explore the role of nucleolin expression in the carcinogenesis
of colon adenocarcinoma, and determine the correlation of the nucleolin expression level with histological
grade in colon adenocarcinoma.
Methods In total, 80 cases of colon adenocarcinoma with cancer-adjacent colon mucosa and 60 cases of
colon adenomas were examined by immunohistochemistry using an antibody against nucleolin. Nucleolin
expression levels in these groups were compared. The correlation between the nucleolin expression level
and grade of colon adenocarcinoma was analyzed.
Results Nucleolin expression is located in the nuclei of colon adenocarcinoma, colon adenoma, and
cancer-adjacent colon mucosa tissues with different intensities. A semiquantitative evaluation using the
Allred scoring system showed that the nucleolin immunostaining score in colon adenocarcinoma (7.8 ± 0.1)
was significantly higher than those in colon adenoma (6.3 ± 0.2) and cancer-adjacent colon mucosa (5.4 ±
0.1; P < 0.01). The nucleolin immunostaining score in colon adenoma was significantly higher than that in
cancer-adjacent colon mucosa (P < 0.01). Nucleolin expression levels in well-differentiated and moderately
differentiated adenocarcinoma (6.8 ± 0.2) were significantly lower than those in poorly differentiated
adenocarcinoma (8.0 ± 0.1; P < 0.01).
Conclusion Increased nucleolin expression may play an important role in the process of malignant
transformation of colon adenocarcinoma and predicts a poor prognosis. |
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