| Gang Song,Shen Lin. Gastric molecular classification and practice in immunotherapy. Oncol Transl Med, 2017, 3: 10-14. |
| Gastric molecular classification and practice in immunotherapy |
| Gastric molecular classification and practice in immunotherapy |
| Received:August 26, 2016 Revised:January 23, 2017 |
| DOI：10.1007/s10330-016-0189-9 |
| 中文关键词: xxx |
| 英文关键词: molecular classification; gastric cancer; immunotherapy |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Gang Song* | Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | happygang11@126.com | | Shen Lin | Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | |
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| 中文摘要: |
| Gastric cancer (GC) is a highly heterogeneous malignant tumor all over the world and prevalence of GC in China is relatively higher. Treatment of advanced GC develops slowly due to lack of proper classification to guide clinical practice. With the development of molecular biological technique, molecular classifications of GC become emerging and show potential value in guiding precise and personalized therapy. Till now, Three to four GC molecular classifications are well known and recognized, including Singapore, the Cancer Genome Atlas Research Network (TCGA), and Asian Cancer Research Group (ACRG) classifications. Here we reviewed development of molecular classifications and characteristics of different subtype, and then discussed application of molecular classification in clinical practice especially in immunotherapy. |
| 英文摘要: |
| Gastric cancer (GC) is a highly heterogeneous malignancy with a high incidence worldwide; the prevalence
of GC is relatively higher in China than in other countries. Treatment of advanced GC has been slow to
develop due to lack of a proper classification system to guide clinical practice. With the development of
molecular biology techniques, the molecular classification of GC has been established and may have applications
in guiding precise and personalized therapy. To date, three or four molecular classifications for
GC have been recognized; these include Singapore, the Cancer Genome Atlas (TCGA) Research Network,
and Asian Cancer Research Group (ACRG) classifications. Here, we review the development of molecular
classifications and characteristics of different subtypes, and discuss the applications of molecular classifications
in clinical practice, with a focus on immunotherapy. |
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