| Yimin Huang,Feng Hu,Kang Wu,Juan Chen,Ran Li,Hao Xu,Ting Lei. Sex-related changes in tumor consistency in prolactinoma patients after bromocriptine pretreatment. Oncol Transl Med, 2016, 2: 203-209. |
| Sex-related changes in tumor consistency in prolactinoma patients after bromocriptine pretreatment |
| Received:August 04, 2016 Revised:September 29, 2016 |
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| KeyWord:prolactinoma; bromocriptine; tumor consistency; surgical outcomes |
| Author Name | Affiliation | E-mail | | Yimin Huang | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | yiminhuang9009@qq.com | | Feng Hu | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | yiminhuang9009@qq.com | | Kang Wu | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | yiminhuang9009@qq.com | | Juan Chen | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | yiminhuang9009@qq.com | | Ran Li | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | yiminhuang9009@qq.com | | Hao Xu | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | yiminhuang9009@qq.com | | Ting Lei | Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. | tlei@tjh.tjmu.edu.cn |
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| Abstract: |
| Objective It has long been reported that prolactinomas treated with bromocriptine increase fibrosis and
may affect surgical outcomes. We retrospectively studied 238 consecutive patients with histopathologically
confirmed prolactinomas undergoing microsurgery in a single neurosurgery department of Tongji Hospital
(Wuhan, China) from 2012 to 2015 in order to evaluate tumor consistency changes after bromocriptine
pretreatment and surgical outcomes.
Methods We divided the patients into four groups: males in the dopamine agonist (DA) group, females
in the DA group, males in the no DA group, and females in the no DA group, and we compared the surgery
process, specimen Masson staining, and clinical outcomes of the four groups. According to a previously
published classification, the operative notes from an experienced neurosurgeon were reviewed to classify
the consistency of tumors as “fibrous” or “nonfibrous”.
Results No differences in tumor consistency were found in male patients with or without DA treatment.
However, in female patients with DA treatment, tumors were likely to be harder in texture than the tumors
of female patients without DA treatment. Despite tumor consistency differences between sexes, the tumor
biological remission rate was similar between groups, as was the rate of tumor resection.
Discussion Our study indicates that preoperative DA therapy impacts tumor consistency in female patients but not male patients. Although the surgical and histopathological outcomes are not influenced, these
findings may provide useful information for the choice of operative approach and surgery process for pituitary adenoma. |
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