| Shuxian Qu,Yongming Liu,Zhaozhe Liu,Liang Liu,Yaling han,xiaodong xie,zhendong zheng. Relationship between peritumoral lymphatic microvessel density and the clinical and pathological characteristics of invasive breast cancer. Oncol Transl Med, 2016, 2: 275-278. |
| Relationship between peritumoral lymphatic microvessel density and the clinical and pathological characteristics of invasive breast cancer |
| Received:July 20, 2016 Revised:December 12, 2016 |
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| KeyWord:breast cancer; lymphatic microvessel density (LMVD); C-erbB-2 |
| Author Name | Affiliation | E-mail | | Shuxian Qu | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | 18624329890@163.com | | Yongming Liu | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | 373141003@qq.com | | Zhaozhe Liu | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | liuzz_summer@163.com | | Liang Liu | Oncology Department, The Third Affiliated Hospital of Guiyang Medical College. | jinshatanwo@163.com | | Yaling han | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | yalinghan@163.com | | xiaodong xie | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | xiexiaodong2008@gmail.com | | zhendong zheng | General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | qushuxian2010@163.com |
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| Abstract: |
| Objective The aim of the study was to determine the morphological characteristics of lymphatic
microvessels and the relationship between lymphatic microvessel density (LMVD) and clinical and
pathological characteristics of invasive breast cancer.
Methods Tissue specimens and clinical pathological data of 51 cases of female breast cancer were
collected in the General Hospital of Shenyang Military Region (Shenyang, China) from January 2007 to
October 2011. Another 20 breast fibroadenoma tissue samples were used as controls. All specimens were
cut into 4-μm slices, and immunohistochemically stained using streptomycin-resistant avidin peroxidase
antibody D2-40. SPSS 17.0 for Windows was used to perform all analyses.
Results A total of 38 breast cancer tissue specimens showed varied staining with monoclonal antibody
D2-40. The rate of positive staining was in these tissues was 74.5% (38/51), which is significantly higher
than that observed in breast fibroadenoma tissues (chi-square = 35.197, P = 0.000). The average LMVD
in 38 cases of breast cancer was (26.46 ± 10.06) microvessels/100× magnification field, which was higher
than that in the control group (t = 10.74, P = 0.000). Microvessels in peritumoral tissues were abundant, with
an average LMVD of (38.42 ± 11.38) microvessels/100× magnification field. Based on layered analysis, the
expression level of peritumoral LMVD was correlated with metastasis of lymph nodes, tumor size, and the
expression of C-erbB-2 (P < 0.05); however, there was no correlation with age or expression of estrogen
receptors or progesterone receptors (P > 0.05).
Conclusion Lymphatic microvessels detected using D2-40 antibody are mainly present in the peritumoral
region of breast cancer tissues, and LMVD showed a correlation with lymph node metastasis and the
expression of C-erbB-2. Positive lymphatic vessels, especially in the peritumoral region, may provide a
path for lymphatic metastasis in breast cancer. Peritumoral LMVD may be used to estimate the prognosis
of patients with breast cancer and may aid in research on treatment methods. |
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