| Shuxian Qu,Yongming Liu,Zhaozhe Liu,Liang Liu,Yaling han,xiaodong xie,zhendong zheng. Relationship between peritumoral lymphatic microvessel density and the clinical and pathological characteristics of invasive breast cancer. Oncol Transl Med, 2016, 2: 275-278. |
| 癌周微淋巴管密度与乳腺浸润性导管癌临床病理特征的相关性 |
| Relationship between peritumoral lymphatic microvessel density and the clinical and pathological characteristics of invasive breast cancer |
| Received:July 20, 2016 Revised:December 12, 2016 |
| DOI：10.1007/s10330-016-0173-3 |
| 中文关键词: 乳腺癌; 微淋巴管密度; C-erbB-2 |
| 英文关键词: breast cancer; lymphatic microvessel density (LMVD); C-erbB-2 |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Shuxian Qu | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | 18624329890@163.com | | Yongming Liu | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | 373141003@qq.com | | Zhaozhe Liu | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | liuzz_summer@163.com | | Liang Liu | Oncology Department, The Third Affiliated Hospital of Guiyang Medical College. | jinshatanwo@163.com | | Yaling han | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | yalinghan@163.com | | xiaodong xie* | Department of Oncology, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | xiexiaodong2008@gmail.com | | zhendong zheng* | General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | qushuxian2010@163.com |
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| 中文摘要: |
| 目的：观察乳腺浸润性导管癌微淋巴管的形态学特点，探讨微淋巴管密度与临床病理特征的相关性。方法：收集2006年1月至2011年10月在沈阳军区总医院就诊的51例女性乳腺癌患者的组织学标本及临床病理数据。20例乳腺纤维腺瘤患者的组织及资料作为对照组。所有的组织标本切成4微米厚的切片，并应用D2-40单抗进行SP免疫组织化学染色。应用SPSS 17.0 for Windows统计软件进行统计分析。结果：38例乳腺癌组织标本出现不同程度的D2-40染色，阳性率为74.5% (38/51)，明显高于对照组(chi-square = 35.197, p = 0.000)。38例阳性乳腺癌组织的平均微淋巴管密度为26.46±10.06microvessels/100×，明显高于对照组(t=10.74, p=0.000)。癌周组织平均微淋巴管密度为38.42±11.38 microvessels/100×，分层分析显示：癌周微淋巴管密度与淋巴结转移数目、肿瘤大小及 C-erbB-2 表达明显相关(P<0.05)，而与年龄及ER/PR的表达无关(P>0.05)。结论：D2-40标记的微淋巴管主要表达在乳腺癌的癌周组织中，可能为乳腺癌转移提供可能的路径，检测阳性微淋巴管密度在一定程度上可指导乳腺癌预后。 |
| 英文摘要: |
| Objective The aim of the study was to determine the morphological characteristics of lymphatic
microvessels and the relationship between lymphatic microvessel density (LMVD) and clinical and
pathological characteristics of invasive breast cancer.
Methods Tissue specimens and clinical pathological data of 51 cases of female breast cancer were
collected in the General Hospital of Shenyang Military Region (Shenyang, China) from January 2007 to
October 2011. Another 20 breast fibroadenoma tissue samples were used as controls. All specimens were
cut into 4-μm slices, and immunohistochemically stained using streptomycin-resistant avidin peroxidase
antibody D2-40. SPSS 17.0 for Windows was used to perform all analyses.
Results A total of 38 breast cancer tissue specimens showed varied staining with monoclonal antibody
D2-40. The rate of positive staining was in these tissues was 74.5% (38/51), which is significantly higher
than that observed in breast fibroadenoma tissues (chi-square = 35.197, P = 0.000). The average LMVD
in 38 cases of breast cancer was (26.46 ± 10.06) microvessels/100× magnification field, which was higher
than that in the control group (t = 10.74, P = 0.000). Microvessels in peritumoral tissues were abundant, with
an average LMVD of (38.42 ± 11.38) microvessels/100× magnification field. Based on layered analysis, the
expression level of peritumoral LMVD was correlated with metastasis of lymph nodes, tumor size, and the
expression of C-erbB-2 (P < 0.05); however, there was no correlation with age or expression of estrogen
receptors or progesterone receptors (P > 0.05).
Conclusion Lymphatic microvessels detected using D2-40 antibody are mainly present in the peritumoral
region of breast cancer tissues, and LMVD showed a correlation with lymph node metastasis and the
expression of C-erbB-2. Positive lymphatic vessels, especially in the peritumoral region, may provide a
path for lymphatic metastasis in breast cancer. Peritumoral LMVD may be used to estimate the prognosis
of patients with breast cancer and may aid in research on treatment methods. |
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