| Dongfang Huang,Jinsheng Wu,Guofeng Chen,Jianhuai Zhang. Primary malignant melanoma of the liver: One case report and literature review. Oncol Transl Med, 2016, 2: 242-245. |
| 肝脏原发性恶性黑色瘤一例并文献分析 |
| Primary malignant melanoma of the liver: One case report and literature review |
| Received:June 16, 2016 Revised:September 22, 2016 |
| DOI：10.1007/s10330-016-0167-3 |
| 中文关键词: 恶性黑色素瘤，肝脏，病理学，免疫组化 |
| 英文关键词: malignant melanoma; liver; pathomorphology; immunohistochemistry |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Dongfang Huang* | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | dong.fanghuang@163.com | | Jinsheng Wu | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | | | Guofeng Chen | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | | | Jianhuai Zhang | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | |
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| 中文摘要: |
| [目的] 肝脏原发性恶性黑色瘤极为罕见。至今据世界文献报道的仅有19例。在这例报告中,通过病理描述及文献复习,是为了提高对该疾病的认识,避免误诊, 对临床治疗及预后提供依据。[方法] 我们通过提供一例61岁中国男性患者患有单发的原发性肝脏恶性黑色素瘤进行研究。[结果]全面的皮肤及眼部检查未发现原发病灶,通过物理检查、相关的辅助检查及全身骨扫描均未发现黑痣及黑色素瘤。该患者术后切除标本送病理检查显示为肝脏恶性黑色素瘤，进一步经免疫组化染色S-100蛋白证实（+），Ki67（30% +），EMA（+），CD10（+），HMB-45（+ +）。[结论] 该病例表明恶性黑色素瘤可以发生在肝脏，当肝脏的其它肿瘤病理学表现不典型时应考虑该病，肝脏恶性黑色瘤的诊断主要依赖临床、影像学及病理组织学，确诊需要病理形态学和免疫组化染色。 |
| 英文摘要: |
| Objective Primary malignant melanomas of the liver are exceedingly rare. Only 19 cases have been
reported in the literature worldwide. In this report, we describe our pathological findings and review the
literature in order to improve our understanding of the disease and prevent misdiagnosis, as well as provide
evidence for its treatment and prognosis.
Methods We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese patient.
Results Comprehensive dermatological and ophthalmological examinations did not reveal any evidence
of a primary cutaneous or ocular lesion. Similarly, serial physical examinations, auxiliary examinations, and
bone scans did not demonstrate any other lesions in the brain, respiratory tract, and gastrointestinal tract.
Microscopic examination of the resected specimen revealed malignant melanoma, which was confirmed by
immunohistochemical staining for S-100 protein ( ), ki67 (30% ), EMA ( ), CD10 ( ), and HMB-45 ( ).
Conclusion Primary malignant melanoma may occur in the liver, and should be considered when the
histopathological appearance is atypical of other hepatic neoplasms. The diagnostic criteria for hepatic
malignant melanoma depend mainly on the clinical, radiographic, and histopathological findings. Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis. |
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