| Dongfang Huang,Jinsheng Wu,Guofeng Chen,Jianhuai Zhang. Primary malignant melanoma of the liver: One case report and literature review. Oncol Transl Med, 2016, 2: 242-245. |
| Primary malignant melanoma of the liver: One case report and literature review |
| Received:June 16, 2016 Revised:September 22, 2016 |
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| KeyWord:malignant melanoma; liver; pathomorphology; immunohistochemistry |
| Author Name | Affiliation | E-mail | | Dongfang Huang | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | dong.fanghuang@163.com | | Jinsheng Wu | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | | | Guofeng Chen | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | | | Jianhuai Zhang | Department of Hepatopancreatobiliary Surgery , Huai'an NO.1 Hospital, the NanJing Medical University, Huai'an 223300, Jiangsu Province, China | |
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| Abstract: |
| Objective Primary malignant melanomas of the liver are exceedingly rare. Only 19 cases have been
reported in the literature worldwide. In this report, we describe our pathological findings and review the
literature in order to improve our understanding of the disease and prevent misdiagnosis, as well as provide
evidence for its treatment and prognosis.
Methods We present a case of an isolated malignant melanoma of the liver in a 61-year-old male Chinese patient.
Results Comprehensive dermatological and ophthalmological examinations did not reveal any evidence
of a primary cutaneous or ocular lesion. Similarly, serial physical examinations, auxiliary examinations, and
bone scans did not demonstrate any other lesions in the brain, respiratory tract, and gastrointestinal tract.
Microscopic examination of the resected specimen revealed malignant melanoma, which was confirmed by
immunohistochemical staining for S-100 protein ( ), ki67 (30% ), EMA ( ), CD10 ( ), and HMB-45 ( ).
Conclusion Primary malignant melanoma may occur in the liver, and should be considered when the
histopathological appearance is atypical of other hepatic neoplasms. The diagnostic criteria for hepatic
malignant melanoma depend mainly on the clinical, radiographic, and histopathological findings. Pathomorphology and immumohistochemical staining can be utilized to confirm the diagnosis. |
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