| Weijing Sun. Molecular subtypes of colorectal cancer: Evaluation of outcomes and treatment. Oncol Transl Med, 2016, 2: 145-149. |
| Molecular subtypes of colorectal cancer: Evaluation of outcomes and treatment |
| Received:June 08, 2016 Revised:July 28, 2016 |
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| KeyWord:colorectal cancer (CRC); molecular subtype; evaluation |
| Author Name | Affiliation | E-mail | | Weijing Sun | University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center (UPMC), University of Pittsburgh Cancer Institute (UPCI) | sunw@upmc.edu |
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| Abstract: |
| Colorectal cancer (CRC) is a biologically heterogeneous disease with diverse clinical outcomes and responses
to treatment. In the past two to three decades, a major effort has focused on classifying colorectal
cancer subtypes based on causation, etiology, gene expression profiles, different pathways, and translational
data from clinical trials. The goal is to uncover prognostic and predictive factors for outcomes in
patients with colorectal cancer and to guide therapeutic approaches and management for the improvement
of overall survival. Significant advances have been achieved in this area. However, tremendous work is still
needed to accomplish the goal of better understanding intratumoral heterogeneity and the influence of the
colonic environment, among other facets of colorectal cancer. |
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