| Yi Li,Ruiqin Yue,Dongrui Qin,Yanqing Wang,Xinling Zhou,Xinyong Jing,Chuanzhong Wu. The diagnostic value of tumor abnormal protein and high sensitivity C reactive protein in screening for endometrial cancer with endometrial thickness less than 8 mm. Oncol Transl Med, 2016, 2: 185-188. |
| 肿瘤异常蛋白联合高敏C反应蛋白对子宫内膜厚小于8mm子宫内膜癌的筛查诊断价值 |
| The diagnostic value of tumor abnormal protein and high sensitivity C reactive protein in screening for endometrial cancer with endometrial thickness less than 8 mm |
| Received:May 27, 2016 Revised:August 11, 2016 |
| DOI：10.1007/s10330-016-0162-8 |
| 中文关键词: 肿瘤异常蛋白；高敏C反应蛋白；子宫内膜厚度；子宫内膜癌 |
| 英文关键词: tumor abnormal protein (TAP); high-sensitivity C-reactive protein (hs-CRP); endometrial thickness; endometrial carcinoma |
| 基金项目:山东省医药卫生科技发展计划项目面上项目（2015WS0407） |
| Author Name | Affiliation | E-mail | | Yi Li* | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Ruiqin Yue | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Dongrui Qin | Department of Pathology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Yanqing Wang | Department of Pathology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Xinling Zhou | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Xinyong Jing | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Chuanzhong Wu | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com |
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| 中文摘要: |
| 目的：探讨肿瘤异常蛋白（TAP）联合高敏C反应蛋白（hs-CRP）对子宫内膜厚小于8mm子宫内膜癌患者的诊断价值。
方法：入选我院2014年9月至2015年12月的最终依赖病理明确诊断但首次超声检查的子宫内膜厚小于8mm的子宫内膜癌19名作为实验组，选取同期最终依赖病理诊断的子宫肌瘤患者26名为对照组，住院时测定两组患者肿瘤异常蛋白（TAP）与高敏C反应蛋白（hs-CRP）水平，统计分析两组患者TAP与hs-CRP表达的差异性。
结果：实验组与对照组中TAP的表达水平分别为182.95±72.14um2、133.19±55.18um2，P=0.019；两组hs-CRP的表达水平分别为7.52±19.03mg/L、1.66±2.31mg/L，P=0.136；TAP对诊断子宫内膜癌的敏感性及特异性分别是73.68%、69.23%；hs-CRP诊断的敏感性及特异性分别是15.79%、100%；TAP及hs-CRP的ROC曲线下面积分别是0.678、0.651，当TAP＞160.662um2，hs-CRP＞1.07mg/L时提示可能是子宫内膜癌。
结论：对于子宫内膜厚小于8mm的子宫内膜癌而言，联合肿瘤异常蛋白（TAP）及高敏C反应蛋白（hs-CRP）检测可以作为一种筛查手段。 |
| 英文摘要: |
| Objective: This study aimed to combine tumor abnormal protein (TAP) and high-sensitivity C-reactive
protein (hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less
than 8 mm, and to provide a reference for clinical screening and diagnosis.
Methods: Clinical data from 19 cases of endometrial cancer, diagnosed on the basis of pathological findings,
were collected from September 2014 to December 2015. The inclusion criteria were as follows: the
patients were first diagnosed with endometrial thickness less than 8 mm and were all in menopause. Perimenopausal
patients (n = 26) with uterine fibroids seen during the same period were selected as a control
group. Serum TAP and hs-CRP levels of the patients in the two groups were simultaneously determined
on admission.
Results: We found that both TAP and hs-CRP levels in the experimental group were higher than those
in the control group [(182.95 ± 72.14) μm2 vs. (133.19 ± 55.18) μm2, P = 0.019; (7.52 ± 19.03) mg/L vs.
(1.66 ± 2.31) mg/L, P = 0.136]. The sensitivity of TAP for the diagnosis of endometrial cancer was 73.68%,
the specificity was 69.23%, and the Youden index was 0.4291. The diagnostic sensitivity and specificity of
hs-CRP was 15.79% and 100%, respectively, and the Youden index was 0.1579. After plotting the receiver
operating characteristics curves, the optimal cut-off value for TAP in diagnosing endometrial cancer was
found to be 160.662 μm2 and that for hs-CRP was 1.07 mg/L.
Conclusion: For patients suspected of having endometrial cancer with endometrial thickness less than 8
mm, combined detection of TAP and hs-CRP levels can be used as a screening tool and can provide new
ideas regarding clinical diagnosis and treatment. |
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