| Fuli Zhang,Huayong Jiang,Weidong Xu,Yadi Wang,Junmao Gao,Qingzhi Liu,Ping Wang,Na Lu,Diandian Chen,Bo Yao,Jun Hou,Heliang He,Jianping Chen. A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer. Oncol Transl Med, 2016, 2: 179-184. |
| A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer |
| Received:March 26, 2016 Revised:July 24, 2016 |
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| KeyWord:flattening filter-free (FFF); cervical cancer; dosimetry; volumetric modulated arc therapy (VMAT) |
| Author Name | Affiliation | E-mail | | Fuli Zhang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | radiozfli@163.com | | Huayong Jiang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | doctorjhy@163.com | | Weidong Xu | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | xwddc@126.com | | Yadi Wang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | wangyadi@hotmail.com | | Junmao Gao | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | gaojunmao1962@163.com | | Qingzhi Liu | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | liu2qing1zhi4@126.com | | Ping Wang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | wangping1956@163.com | | Na Lu | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zeng@163.com | | Diandian Chen | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zeng1@163.com | | Bo Yao | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zeng2@163.com | | Jun Hou | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zgeng3@163.com | | Heliang He | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zgeng4@163.com | | Jianping Chen | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zgeng5@163.com |
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| Abstract: |
| Objective: The aim of the study was to compare flattening filter-free (FFF) beams and conventional flattening
filter (FF) beams in volumetric modulated arc therapy (VMAT) for cervical cancer after surgery,
through a retrospective planning study.
Methods: VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients.
The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume
received this dose. Doses were computed with a commercially available treatment planning system using a
Monte Carlo (MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms
of planning target volume homogeneity and conformity indices (HI and CI), as well as organs at risk (OAR)
dose and volume parameters.
Results: FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No
statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including
pelvic bone marrow, small bowel, bladder, rectum, and normal tissue (NT). .
Conclusion: For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR
dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial. |
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