| Fuli Zhang,Huayong Jiang,Weidong Xu,Yadi Wang,Junmao Gao,Qingzhi Liu,Ping Wang,Na Lu,Diandian Chen,Bo Yao,Jun Hou,Heliang He,Jianping Chen. A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer. Oncol Transl Med, 2016, 2: 179-184. |
| 无均整块容积旋转调强技术在宫颈癌术后放疗计划中的剂量学评估 |
| A dosimetric evaluation of flattening filter-free volumetric modulated arc therapy for postoperative treatment of cervical cancer |
| Received:March 26, 2016 Revised:July 24, 2016 |
| DOI：10.1007/s10330-016-0154-8 |
| 中文关键词: 无均整块；剂量学；容积旋转调强放疗 |
| 英文关键词: flattening filter-free (FFF); cervical cancer; dosimetry; volumetric modulated arc therapy (VMAT) |
| 基金项目:全军医学计量专项课题 (No.2011-JL2-005) |
| Author Name | Affiliation | E-mail | | Fuli Zhang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | radiozfli@163.com | | Huayong Jiang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | doctorjhy@163.com | | Weidong Xu | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | xwddc@126.com | | Yadi Wang* | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | wangyadi@hotmail.com | | Junmao Gao | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | gaojunmao1962@163.com | | Qingzhi Liu | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | liu2qing1zhi4@126.com | | Ping Wang | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | wangping1956@163.com | | Na Lu | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zeng@163.com | | Diandian Chen | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zeng1@163.com | | Bo Yao | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zeng2@163.com | | Jun Hou | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zgeng3@163.com | | Heliang He | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zgeng4@163.com | | Jianping Chen | Radiation Oncology Department, The PLA Army General Hospital of China, Beijing 100700, China | zgeng5@163.com |
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| 中文摘要: |
| 目的: 通过一项回顾性研究比较无均整块和有均整块容积旋转调强技术（VMAT）在宫颈癌术后放疗计划中的剂量学差异。
材料与方法: 选择15例患者, 分别设计无均整块（FFF-VMAT）和有均整块（FF-VMAT）的VMAT计划，处方剂量45Gy， 单次1.8Gy， 至少95%的靶区体积接受此处方剂量。 采用Monte Carlo算法计算剂量，根据剂量-体积直方图 （DVH）比较靶区（Dmax、Dmin、Dmean、HI、CI）和各危及器官的剂
结果: FFF-VMAT与FF-VMAT计划适形度接近，但前者的均匀性略差于后者，骨髓、小肠、膀胱、直肠等危及器官的多数剂量-体积参数无显著性差异（p>0.05）。
结论: 对于宫颈癌术后放疗患者， FFF-VMAT与FF-VMAT计划相差不大，但FFF-VMAT计划明显降低了治疗过程的出束时间，可使患者临床获益。 |
| 英文摘要: |
| Objective: The aim of the study was to compare flattening filter-free (FFF) beams and conventional flattening
filter (FF) beams in volumetric modulated arc therapy (VMAT) for cervical cancer after surgery,
through a retrospective planning study.
Methods: VMAT plans of FFF beams and normal FF beams were designed for a cohort of 15 patients.
The prescribed dose was 45 Gy to 1.8 Gy per fraction, and at least 95% of the planning target volume
received this dose. Doses were computed with a commercially available treatment planning system using a
Monte Carlo (MC) algorithm. Plans were compared according to dose-volume histogram analysis in terms
of planning target volume homogeneity and conformity indices (HI and CI), as well as organs at risk (OAR)
dose and volume parameters.
Results: FFF-VMAT was similar to FF-VMAT in terms of CI, but inferior to FF-VMAT considering HI. No
statistically differences were observed between FFF-VMAT and FF-VMAT in following organ at risks including
pelvic bone marrow, small bowel, bladder, rectum, and normal tissue (NT). .
Conclusion: For patients with cervical cancer after hysterectomy, the FFF beam achieved target and OAR
dose distribution similar to that of the FF beam. Reduction of beam-on time in cervical cancer is beneficial. |
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