| Qianqian Yu,Hong Qiu,Mingsheng Zhang,Guangyuan Hu,Liu Huang,Xianglin Yuan. Prognostic value of the neutrophil-to-lymphocyte ratio in metastatic colorectal cancer*. Oncol Transl Med, 2016, 2: 75-79. |
| 中性粒细胞与淋巴细胞比值在转移性结直肠癌中的预后价值 |
| Prognostic value of the neutrophil-to-lymphocyte ratio in metastatic colorectal cancer* |
| Received:January 09, 2016 Revised:April 06, 2016 |
| DOI：10.1007/s10330-016-0130-3 |
| 中文关键词: 转移性结直肠癌；预后；中性粒细胞与淋巴细胞比值 |
| 英文关键词: metastatic colorectal cancer (mCRC); outcome; neutrophil-to-lymphocyte ratio (NLR) |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）；湖北省自然科学基金项目 |
| Author Name | Affiliation | E-mail | | Qianqian Yu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | yqq0258@163.com | | Hong Qiu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | tjqiuhong@163.com | | Mingsheng Zhang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | zms75@163.com | | Guangyuan Hu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | h.g.y.121@163.com | | Liu Huang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | huangliu017@163.com | | Xianglin Yuan* | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | yxl@medmail.com.cn |
|
| Hits: 8855 |
| Download times: 11050 |
| 中文摘要: |
| 目的：本研究的目的是探索在接受以伊立替康为基础的一线化疗方案治疗的转移性结直肠癌患者中，中性粒细胞与淋巴细胞比值（NLR） 的对于临床预后的预测价值。方法：本研究基于一项中国人群的前瞻性多中心的临床试验（NCT01282658）。我们记录了基线的血细胞计数。生存曲线由Kaplan-Meier方法决定。生物标志物的独立预测作用由基于Cox回归模型的多因素分析来决定。结果：139例患者被评估。小于中位值的NLR与较好地无进展生存期（PFS）相关（9.9月 vs 7.7月，p = 0.043），与较好的总生存（OS）相关（21.8月 vs. 15.1月，p = 0.013）。这些结果在多因素分析中依然具有统计学意义。结论：NLR是中国人群中接受伊立替康为基础的化疗方案的转移性结直肠癌患者的独立的预后因素。 |
| 英文摘要: |
| Objective?This study investigated the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) in predicting clinical outcomes of patients with metastatic colorectal cancer (mCRC) undergoing irinotecan-based first-line chemotherapy.
Methods?This study was based on a Chinese prospective multicenter trial (NCT01282658). Baseline complete blood cell counts were performed. Survival was determined using the Kaplan-Meier method. Multivariate analyses based on the Cox regression model were performed to determine the effects of independent biomarkers.
Results?A total of 139 patients were evaluated. Values below the median NLR were associated with better progression-free survival (PFS) (9.9 vs 7.7 months, P = 0.043) and overall survival (OS) (21.8 vs 15.1 months, P = 0.013). These effects remained significant in multivariate analysis.
Conclusion?NLR is an independent prognostic marker of mCRC treated with first-line irinotecan-based therapy in a Chinese population.
|
|
View Full Text
Download reader HTML全文 |
| Close |
|
|
|