Huandi Zhou,Xiaohui Ge,Xiaoying Xue. microRNAs regulation and its role as biomarkers in diseases. Oncol Transl Med, 2016, 2: 39-46. |
microRNAs regulation and its role as biomarkers in diseases |
Received:August 04, 2015 Revised:January 25, 2016 |
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KeyWord:MicroRNA; cancer; disease; drug |
Author Name | Affiliation | E-mail | Huandi Zhou | Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | huandizhou@126.com | Xiaohui Ge | Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | xiaozihuirain@163.com | Xiaoying Xue | Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | xxy6412@163.com |
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Abstract: |
MicroRNAs (miRNAs), approximately 21 to 23 nucleotides (nt) in length, belong to a set of small non-coding
RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles
in many diseases such as various kinds of cancers and immune disorders. Many studies have focused on
the relationship between miRNAs and diseases. miRNAs are significant mediators in human growth and
development and in the genesis and development of diseases. Almost 30% of the activity of protein-coding
genes is forecasted to be regulated by miRNAs in mammals, and some miRNAs are regarded as potential
therapeutic targets for various diseases. In this review, we outline some functions of miRNAs, especially
those related to diseases. |
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