| Huandi Zhou,Xiaohui Ge,Xiaoying Xue. microRNAs regulation and its role as biomarkers in diseases. Oncol Transl Med, 2016, 2: 39-46. |
| MicroRNA与疾病的研究进展 |
| microRNAs regulation and its role as biomarkers in diseases |
| Received:August 04, 2015 Revised:January 25, 2016 |
| DOI：10.1007/s10330-015-0116-6 |
| 中文关键词: MicroRNA;癌症;microRNA和疾病;药物 |
| 英文关键词: MicroRNA; cancer; disease; drug |
| 基金项目:河北省自然科学基金项目（C2009001151） |
| Author Name | Affiliation | E-mail | | Huandi Zhou | Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | huandizhou@126.com | | Xiaohui Ge | Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | xiaozihuirain@163.com | | Xiaoying Xue* | Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China | xxy6412@163.com |
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| 中文摘要: |
| MicroRNAs是一类非编码RNA，长度为21~23个核苷酸。最初，microRNA 被认为是没有功能的。microRNA在许多疾病例如各种肿瘤和免疫系统中发挥着很重要的作用。目前许多研究聚焦于miRNAs和疾病的关系方面。miRNA在人类生长发育以及疾病发生发展方面起到重要的调节作用。在哺乳动物中，miRNA广泛调节了将近30%的蛋白编码基因的活性。一些miRNA有可能成为各种疾病的治疗靶点。本文针对microRNA的功能，尤其是和疾病相关的功能进行的概括描述。 |
| 英文摘要: |
| MicroRNAs (miRNAs), approximately 21 to 23 nucleotides (nt) in length, belong to a set of small non-coding
RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles
in many diseases such as various kinds of cancers and immune disorders. Many studies have focused on
the relationship between miRNAs and diseases. miRNAs are significant mediators in human growth and
development and in the genesis and development of diseases. Almost 30% of the activity of protein-coding
genes is forecasted to be regulated by miRNAs in mammals, and some miRNAs are regarded as potential
therapeutic targets for various diseases. In this review, we outline some functions of miRNAs, especially
those related to diseases. |
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