| Heng Cao,Yonggui Hong,Shouran Zhao,Nengchao Wang,Fuyou Zhou,Xiaodong Xie. Prognostic factors for the survival of 66 cases with extensive stage-small cell lung cancer. Oncol Transl Med, 2016, 2: 12-15. |
| 66例广泛期小细胞肺癌患者的预后分析 |
| Prognostic factors for the survival of 66 cases with extensive stage-small cell lung cancer |
| Received:June 21, 2015 Revised:January 28, 2016 |
| DOI：10.1007/s10330-015-0110-z |
| 中文关键词: 小细胞肺癌 广泛期 生存率 预后 |
| 英文关键词: extensive stage-small cell lung cancer (ES-SCLC); survival rate; prognosis |
| 基金项目:中国科学院重大资助项目（含外籍） |
| Author Name | Affiliation | E-mail | | Heng Cao | Department of Oncology, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang | caoheng123jun@126.com | | Yonggui Hong | Department of Oncology, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang | caoheng123jun@126.com | | Shouran Zhao | Department of Oncology, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang | caoheng123jun@126.com | | Nengchao Wang | Department of Oncology, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang | caoheng123jun@126.com | | Fuyou Zhou | Department of Oncology, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang | 395648947@qq.com | | Xiaodong Xie* | Department of Oncology, The General Hospital of Shenyang Military, Shenyang 110840, China | 67621527@qq.com |
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| 中文摘要: |
| 摘要 目的：本研究旨在分析广泛期小细胞肺癌的独立预后因素。方法：回顾性分析安阳市肿瘤医院2005年7月至2009年7月治疗的66例广泛期小细胞肺癌的临床资料，所有患者均经组织病理或细胞学确诊。生存分析采用Kaplan-Meier法计算生存率，Log-rank检验进行单因素分析，并对有意义的单因素通过Cox风险模型筛选影响预后因素。结果：广泛期患者1、2、3年生存率分别为40.9%、13.6%、6.1%，中位生存时间为10个月。单因素分析显示体重减轻情况、一线化疗疗效、总化疗周期数、治疗方式、低钠血症与患者预后相关，具有统计学差异。多因素分析显示一线化疗疗效、总化疗周期数、低钠血症对患者的总生存时间具有显著影响。结论：一线化疗疗效、总化疗周期数和低钠血症是影响广泛期小细胞肺癌的独立预后因素。 |
| 英文摘要: |
| Objective: The objective of this retrospective study was to investigate the prognostic factors associated
with survival among patients with extensive stage-small cell lung cancer (ES-SCLC).
Methods: Clinical data from 66 patients with ES-SCLC diagnosed via histopathology or cytology between
July 2005 and July 2009 at Anyang Tumor Hospital (China) were analyzed. Univariate and multivariate
Kaplan-Meier, log-rank, and Cox proportional hazard regression analyses were conducted.
Results: The 12-, 24-, and 36-month survival rates among patients with ES-SCLC were 40.9%, 13.6%,
and 6.1%, respectively. The median survival time (MST) was 10 months. Univariate analyses indicated
that weight loss, efficacy of first-line chemotherapy, total number of chemotherapy cycles, treatment method,
and serum sodium levels significantly influenced survival among patients with ES-SCLC. Multivariate
analyses suggested that the efficacy of first-line chemotherapy, total number of chemotherapy cycles, and
serum sodium levels were independent prognostic factors associated with survival.
Conclusion: The efficacy of first-line chemotherapy, total number of chemotherapy cycles, and serum
sodium levels are important prognostic factors for patients with ES-SCLC. |
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