Yanchun Wang,Shan Hu,Xuemei Hu,Jianjun Li,Yaqi Shen,Xiaoyu Liu,Zhi Wang,Xiaoyan Meng,Zhen Li,Daoyu Hu. Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study. Oncol Transl Med, 2015, 1: 164-170.
Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study
Received:June 15, 2015  Revised:July 21, 2015
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KeyWord:diffusion-weighted imaging; magnetic resonance imaging (MRI); investigate the ability of intravoxel incoherent motion (IVIM); cervical cancer; radiochemotherapy
Author NameAffiliationE-mail
Yanchun Wang Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 574070861@qq.com 
Shan Hu Department of Radiology, Guangdong General Hospital, Guangzhou 510080, China 27355432@qq.com 
Xuemei Hu Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 447829118@qq.com 
Jianjun Li Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 66872473@qq.com 
Yaqi Shen Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 464615327@qq.com 
Xiaoyu Liu Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 596906920@qq.com 
Zhi Wang Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 282926858@qq.com 
Xiaoyan Meng Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China 461207401@qq.com 
Zhen Li Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China zhenli@hust.edu.cn 
Daoyu Hu Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China cjr.hudaoyu@vip.163.com 
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Abstract:
      Objective?The aim of this study was to investigate the ability of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) to diagnose cervical cancer and to evaluate the response of uterine cervical cancer to radiochemotherapy (CRT). Methods?This prospective study was approved by the institutional review board, and informed consent was obtained from all patients. A total of 23 patients with primary cervical cancer who were undergoing CRT and 16 age-matched healthy subjects were prospectively recruited for IVIM (b = 0–800 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive f (perfusion fraction), D* (pseudo-diffusion coefficient), and D (true molecular diffusion coefficient) in cervical cancer (n = 23) and the normal cervix (n = 16). The apparent diffusion coefficient (standard ADC) was calculated. The independent-samples t-test and paired-samples t-test were used for comparisons. Results?Pre-treatment cervical cancer had the lowest standard ADC (1.15 ± 0.13 × 10-3 mm2/s) and D (0.89 ± 0.10 × 10-3 mm2/s) values, and these were significantly different from the normal cervix and post-treatment cervical cancer (P = 0.00). The f (16.67 ± 5.85%) was lowest in pre-treatment cervical cancer and was significantly different from the normal cervix and post-treatment cervical cancer (p = 0.012 and 0.00, respectively). No difference was observed in D*. Conclusion?IVIM is potentially promising for differentiating between the normal cervix and cervical cancer because pre-treated cervical cancer has low perfusion and diffusion IVIM characteristics. Further, the standard ADC, D, and f of cervical cancer showed a tendency to normalize after CRT; thus, IVIM may be useful for monitoring the response to CRT in cervical cancer.
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