Yanchun Wang,Shan Hu,Xuemei Hu,Jianjun Li,Yaqi Shen,Xiaoyu Liu,Zhi Wang,Xiaoyan Meng,Zhen Li,Daoyu Hu. Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study. Oncol Transl Med, 2015, 1: 164-170. |
Intravoxel incoherent motion magnetic resonance imaging for diagnosis of cervical cancer and evaluation of response of uterine cervical cancer to radiochemotherapy: A pilot study |
Received:June 15, 2015 Revised:July 21, 2015 |
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KeyWord:diffusion-weighted imaging; magnetic resonance imaging (MRI); investigate the ability of intravoxel incoherent motion (IVIM); cervical cancer; radiochemotherapy |
Author Name | Affiliation | E-mail | Yanchun Wang | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 574070861@qq.com | Shan Hu | Department of Radiology, Guangdong General Hospital, Guangzhou 510080, China | 27355432@qq.com | Xuemei Hu | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 447829118@qq.com | Jianjun Li | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 66872473@qq.com | Yaqi Shen | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 464615327@qq.com | Xiaoyu Liu | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 596906920@qq.com | Zhi Wang | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 282926858@qq.com | Xiaoyan Meng | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | 461207401@qq.com | Zhen Li | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | zhenli@hust.edu.cn | Daoyu Hu | Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | cjr.hudaoyu@vip.163.com |
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Abstract: |
Objective?The aim of this study was to investigate the ability of intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) to diagnose cervical cancer and to evaluate the response of uterine cervical cancer to radiochemotherapy (CRT).
Methods?This prospective study was approved by the institutional review board, and informed consent was obtained from all patients. A total of 23 patients with primary cervical cancer who were undergoing CRT and 16 age-matched healthy subjects were prospectively recruited for IVIM (b = 0–800 s/mm2) and standard pelvic MRI. Bi-exponential analysis was performed to derive f (perfusion fraction), D* (pseudo-diffusion coefficient), and D (true molecular diffusion coefficient) in cervical cancer (n = 23) and the normal cervix (n = 16). The apparent diffusion coefficient (standard ADC) was calculated. The independent-samples t-test and paired-samples t-test were used for comparisons.
Results?Pre-treatment cervical cancer had the lowest standard ADC (1.15 ± 0.13 × 10-3 mm2/s) and D (0.89 ± 0.10 × 10-3 mm2/s) values, and these were significantly different from the normal cervix and post-treatment cervical cancer (P = 0.00). The f (16.67 ± 5.85%) was lowest in pre-treatment cervical cancer and was significantly different from the normal cervix and post-treatment cervical cancer (p = 0.012 and 0.00, respectively). No difference was observed in D*.
Conclusion?IVIM is potentially promising for differentiating between the normal cervix and cervical cancer because pre-treated cervical cancer has low perfusion and diffusion IVIM characteristics. Further, the standard ADC, D, and f of cervical cancer showed a tendency to normalize after CRT; thus, IVIM may be useful for monitoring the response to CRT in cervical cancer.
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