| Xia Zhang,Xiaodi Deng,Yu Zhang,Zhiguang Li. Novel patterns of cancer genome evolution. Oncol Transl Med, 2015, 1: 222-225. |
| 癌症基因组进化的新模式 |
| Novel patterns of cancer genome evolution |
| Received:June 12, 2015 Revised:September 11, 2015 |
| DOI：10.1007/s10330-015-0103-y |
| 中文关键词: 癌症基因组；进化；染色体碎裂；染色体链条可变性重排 |
| 英文关键词: Cancer genome; evolution; chromothripsis; chromoplexy |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xia Zhang | Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University, Dalian 116044, China | zhangxia864@126.com | | Xiaodi Deng | Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University, Dalian 116044, China | zhiguangli@dlmedu.edu.cn | | Yu Zhang | Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University, Dalian 116044, China | zhiguangli@dlmedu.edu.cn | | Zhiguang Li* | Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University, Dalian 116044, China | zhiguangli@dlmedu.edu.cn |
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| 中文摘要: |
| 细胞通常经过漫长的演化之旅，由正常细胞、癌前病变细胞，演化为一个成熟的癌细胞。在这个旅程中，细胞获得许多基因畸变，或者是赋予细胞显著生长优势的驱动突变，或者是不影响肿瘤生长的伴随突变。测序技术的最新进展，通过评估突变等位基因的相对数量，在全基因组水平破译癌细胞的进化过程成为可行。chromothripsis和chromoplexy这样的专业术语被引入，以描述癌症基因组进化的新模式。这些新的观点极大地扩大了我们对癌症是如何开始和发展的理解，有助于提高癌症管理和治疗的效率。 |
| 英文摘要: |
| Cells usually undergo a long journey of evolution during the progression from normal to precancerous cells and finally to full-fledged cancer cells. Multiple genomic aberrations are acquired during this journey that could either act as drivers to confer significant growth advantages or act as passengers with little effect on the tumor growth. Recent advances in sequencing technology have made it feasible to decipher the evolutionary course of a cancer cell on a genome-wide level by evaluating the relative number of mutated alleles. Novel terms such as chromothripsis and chromoplexy have been introduced to describe the newly identified patterns of cancer enome evolution. These new insights have greatly expanded our understanding of the initiation and progression of cancers, which should aid in improving the efficiency of cancer management and treatment. |
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