| Feiying Xiao. Clinical and pathological observations of retroperitoneal paraganglioma in 32 cases. Oncol Transl Med, 2015, 1: 218-221. |
| 32 例腹膜后副神经节瘤的临床病理观察 |
| Clinical and pathological observations of retroperitoneal paraganglioma in 32 cases |
| Received:May 29, 2015 Revised:October 06, 2015 |
| DOI：10.1007/s10330-015-0097-5 |
| 中文关键词: 腹膜后副神经节瘤； 免疫组织化学 |
| 英文关键词: retroperitoneal paraganglioma; immunohistochemistry; pathology |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Feiying Xiao* | Department of Pathology, Zhejiang Province Tumour Hospital, Hangzhou 310022, China | 19149552@qq.com |
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| 中文摘要: |
| 探讨腹膜后副神经节瘤的临床表现、病理特征及鉴别诊断。 方法 分析32例腹膜后副神经节瘤患者的临床特征、组织形态、免疫表型特点、治疗及预后，并复习相关文献。结果 大部分患者以腰背酸痛为主要症状就诊，常伴有血压升高。副神经节瘤切面血管丰富，镜下肿瘤细胞胞浆丰富，部分嗜碱性，免疫组化ＣｇＡ、Ｓｙｎ、Ｓ?１００、Ｋｉ?６7（２％～３０％）阳性表达，Ｍｅｌａｎ?Ａ、ＣＫ 均不表达。治疗以手术切除为主。获随访的13例患者均未见肿瘤复发转移。结论 腹膜后副神经节瘤的定性诊断主要依靠形态学观察，免疫组化可以辅助诊断和鉴别。腹膜后副神经节瘤是潜在的恶性肿瘤，术后应长期随访。 |
| 英文摘要: |
| Objective: The aim of the study was to investigate the clinical manifestations, pathologic features, differentiation, and diagnosis of retroperitoneal paraganglioma.
Methods: The clinical manifestations, histopathologic morphology, immunohistologic features, treatment, and prognosis were analyzed in 32 cases of retroperitoneal paraganglioma, and the literature was reviewed.
Results: Low back pain was the main symptom of retroperitoneal paraganglioma, and patients often presented with increased blood pressure. Blood vessels were abundant in the neoplasm of retroperitoneal paraganglioma, and pathologic diagnosis showed that the cells of tumors were rich in cytoplasm, and some were basophilic. Immunohistochemical study showed that CgA, Syn, S-100, and Ki-67 (2%–30%) were expressed, while Melan-A and CK were not. The patients were treated with surgical resection. Thirteen cases were followed up, and no recurrence or metastases have been observed.
Conclusion: The diagnosis of retroperitoneal paraganglioma should be confirmed by morphologic features and immunophenotype. Patients should be followed-up due to the potential for malignancy. |
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