| Yingying Li,Sunan Wang,Peking University Shenzhen Hospital. Pathological characteristics and immunophenotype analysis of cervical intraepithelial neoplasia. Oncol Transl Med, 2016, 2: 285-289. |
| 子宫颈上皮内瘤变临床病理特点及免疫表型分析 |
| Pathological characteristics and immunophenotype analysis of cervical intraepithelial neoplasia |
| Received:May 15, 2015 Revised:May 15, 2015 |
| DOI：10.1007/s10330-015-0096-6 |
| 中文关键词: 子宫颈上皮内瘤变；临床病理；基因蛋白；免疫组织化学 |
| 英文关键词: cervical intraepithelial neoplasia; clinical pathology; protein; immunohistochemistry |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Yingying Li | Shenzhen Polytechnic College | wyk_150@163.com | | Sunan Wang* | Shenzhen Polytechnic College | wyk_150@163.com | | Peking University Shenzhen Hospital | Peking University Shenzhen Hospital | |
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| 中文摘要: |
| 目的：探讨子宫颈上皮内瘤变临床病理特点及免疫表型。方法：采用免疫组织化学技术检测了59例上皮内瘤病变(CIN) 、20例宫颈鳞癌和20例正常宫颈组织中p16、p53、bcl-2、和C-erbB-2表达情况。结果：p16、p53、bcl-2和C-erbB-2在CIN、宫颈鳞癌和正常宫颈组织中阳性率分别为76.3％（45/59）、28.8％（17/59）、61.0％（36/59）、40.0％（23/59）；60.0％（12/20）、60.0％（12/20）、75.0％（15/20）、65.0％（13/20）；0.0％（0/20）、0.0％（0/20）、35.0％（7/20）、0.0％（0/20）。p16、p53、 bcl-2在鳞癌、CIN中的表达与正常组织之间差异有显著性（p﹤0.001）, 鳞癌与CIN之间差异无显著性（p﹥0.05）；C-erbB-2、p53在鳞癌、CIN与正常组织中的表达有显著差异（p﹥0.05）；bcl-2、C-erbB-2、p53在CIN 3级组与CINI 1级、CIN 2级组之间差异有显著性（p﹤0.05）。结论: bcl-2过表达是宫颈癌发生的早期事件，p16 、C-erbB-2过表达是细胞恶性变的标志，p53的表达与宫颈癌发生、发展有关。 |
| 英文摘要: |
| Objective To explore the clinical pathological features and immunophenotypes of cervical intraepithelial
neoplasia (CIN).
Methods The protein expression of p16, p53, Bcl-2, and c-erbB-2 in 59 cases of CIN, 20 cases of cervical
squamous cell carcinoma, and 20 cases of normal cervical tissues were tested using immunohistochemistry
staining.
Results The expression rates of p16, p53, Bcl-2, and c-erbB-2 in CIN tissues were 76.3% (45/59), 28.85
(17/59), 61.0% (36/59), and 40.0% (23/59), respectively. The expression rates of p16, p53, Bcl-2, and
c-erbB-2 in cervical squamous cell carcinoma tissues were 60.0% (12/20), 60.0% (12/20), 75.0% (15/20),
and 65.0% (13/20), respectively. The expression rates of p16, p53, Bcl-2, and c-erbB-2 in normal cervical
tissues were 0.0% (0/20), 0.0% (0/20), 35.0% (7/20), 0.0% (0/20), respectively. In comparison to normal
tissues, the differential expressions of p16, p53, and Bcl-2 in squamous cell carcinoma and CIN were
statistically significant (P <0.001), whereas the difference between the squamous cell carcinoma and CIN
was not significant (P >0.05). In comparison to normal tissues, the differential expressions of c-erbB-2
and p53 in squamous cell carcinoma and CIN were statistically significant (P >0.05). The differential
expressions of Bcl-2, c-erbB-2, and p53 in CIN 3 were statistically significant in comparison to CIN 1 and
CIN 2 (P <0.05).
Conclusion Overexpression of Bcl-2 occurs early in the development of cervical cancer, whereas p16
and c-erbB-2 overexpression are markers for cell malignancy. The expression of p53 is correlated with the
development of cervical cancer. |
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