| Junbao Liu,Chengxu Cui,Lifang Yuan,Jinwan Wang,Shuping Shi,Zhujun Shao,Haijian Tang,Tingting Yang,Chunhui Gao,Nang Wang,Wei Liu. Advanced duodenal carcinoma: Chemotherapy efficacy and analysis of prognostic factors. Oncol Transl Med, 2016, 2: 16-20. |
| 晚期十二指肠癌化疗的方案、疗效比较及预后分析 |
| Advanced duodenal carcinoma: Chemotherapy efficacy and analysis of prognostic factors |
| Received:May 03, 2015 Revised:February 01, 2016 |
| DOI：10.1007/s10330-015-0094-8 |
| 中文关键词: 原发十二指肠癌;姑息性化疗;生存期；预后因素 |
| 英文关键词: primary duodenal carcinoma (PDC); palliative chemotherapy; survival; prognostic factors |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Junbao Liu | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | liujb1@sohu.com | | Chengxu Cui* | Department of Medical Oncology, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking | cuichengxu@csco.org.cn | | Lifang Yuan | Department of Medical Oncology, Chaoyang Huanxing Cancer Hospital, Beijing 100122, China | yuanlf122@sohu.com | | Jinwan Wang | Department of Medical Oncology, Cancer Hospital & Institute, Chinese Academy of Medical Sciences & Peking | wjw@sohu.com | | Shuping Shi | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | ssp@sohu.com | | Zhujun Shao | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | szj@sohu.com | | Haijian Tang | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | thj@sohu.com | | Tingting Yang | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | ytt@sohu.com | | Chunhui Gao | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | gch@sohu.com | | Nang Wang | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | wn@sohu.com | | Wei Liu | Department of Medical Oncology, Chaoyang Sanhuan Cancer Hospital, Beijing 100122, China | lw@sohu.com |
|
| Hits: 10051 |
| Download times: 13320 |
| 中文摘要: |
| 摘要 目的：通过回顾性分析晚期原发十二指肠癌的化疗疗效及，探索十二指肠癌的有效化疗方案预后因素。方法：选取晚期原发十二指肠癌患者73例，分析化疗的有效率、疾病控制率，对无进展生存及总生存率的影响。结果：可评价疗效的患者52例，化疗总有效率21.5%，疾病控制率69.23%. 化疗患者的无进展生存（PFS）和所有患者总生存（OS）分别为4.5个月和11.47个月。同未化疗患者相比，化疗延长晚期原发十二指肠癌患者的生存时间（14.28个月vs. 5.20个月，HR=0.205，95%CI：0.077-0.547，P=0.000 5）。多因素分析表明，肝转移及病理检测存在黏液腺癌组织是十二指肠癌的独立预后因素。结论：姑息性化疗可能提高晚期十二指肠癌患者的总生存。 |
| 英文摘要: |
| Objective: This study aimed to determine the efficacy of chemotherapy and to identify potential chemotherapy agents to treat advanced primary duodenal carcinoma (PDC).
Methods: Seventy-three patients with advanced PDC were included in the study. Response rate (RR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS) and prognosis were compared among patients using the Cox proportional hazards model.
Results: The overall RR and DCR of 52 patients were 21.15% and 69.23%, respectively. The median PFS and OS times were 4.51 and 11.47 months, respectively. Palliative chemotherapy improved the OS of patients with advanced PDC compared with patients who did not receive chemotherapy (14.28 months vs. 5.20 months, HR = 0.205, 95% CI: 0.077 to 0.547, P = 0.0016). Multivariate analysis indicated mucinous histology and liver metastasis as factors predictive of poor prognosis in patients with advanced PDC.
Conclusion: Palliative chemotherapy may improve the OS of patients with advanced PDC. Mucinous histology and liver metastasis were the main prognostic factors in patients with advanced PDC. |
|
View Full Text
Download reader HTML全文 |
| Close |
|
|
|