| Lan Yang,Jiaobo Zhu,Xiaoyue Song,Yan Qi,Xiaobin Cui,Feng Li. Human papillomavirus-associated diseases and cancers. Oncol Transl Med, 2015, 1: 109-114. |
| 人乳头状瘤病毒感染相关疾病及肿瘤 |
| Human papillomavirus-associated diseases and cancers |
| Received:April 27, 2015 Revised:June 05, 2015 |
| DOI：10.1007/s10330-015-0092-x |
| 中文关键词: 人乳头状瘤病毒; 低危型HPV; 高危型HPV; 肿瘤 |
| 英文关键词: human papillomavirus (HPV); low-risk; high-risk; cancer |
| 基金项目:国家自然科学基金项目 |
| Author Name | Affiliation | E-mail | | Lan Yang | Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi | yl-branda@163.com | | Jiaobo Zhu | Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi | 903667821@qq.com | | Xiaoyue Song | Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi | 251856120@qq.com | | Yan Qi | Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi | 1239936182@qq.com | | Xiaobin Cui | Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi | 342029924@qq.com | | Feng Li* | Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases,Shihezi University School of Medicine,Shihezi | 2642419294@qq.com |
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| 中文摘要: |
| 人乳头状瘤病毒(Human Papillomavirus，HPVs) 最早是在宫颈癌细胞和皮肤乳头状细胞中被检测到，HPV包括多种类型可被分为低危型和高危型, HPV致瘤机制中，其染色体的复制需要整合到宿主细胞DNA上，HPV编码蛋白能够诱导上皮细胞的分化，导致肿瘤的发生。不同类型HPV 能够引起不同类型的良性或恶性病变，本文主要阐述了不同HPV类型与其相关的疾病和肿瘤以及HPV感染相关疾病的治疗和防治措施。 |
| 英文摘要: |
| Human papillomaviruses (HPVs) have been detected in cervical cancer cells and skin papilloma cells, which have a variety of types, including low-risk and high-risk types. HPV genome replication requires the host cell’s DNA synthesis machinery, and HPVs encode proteins that maintain differentiated epithelial cells
in a replication-competent state. HPV types are tissue-specific and generally produce different types of lesions, either benign or malignant. This review examines different HPV types and their associated diseases and presents therapeutic options for the treatment of HPV-positive diseases. |
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