| Miao Li,Jun Li,Zhaozhen Qi,Qiu Tang,Xiangyang Wang,Hongda Lu. Role of inflammatory gene variants in Helicobacter pylori-related gastric cancer. Oncol Transl Med, 2015, 1: 104-108. |
| 炎症基因变异在幽门螺旋杆菌相关性胃癌中的研究进展 |
| Role of inflammatory gene variants in Helicobacter pylori-related gastric cancer |
| Received:March 26, 2015 Revised:May 29, 2015 |
| DOI：10.1007/s10330-015-0084-x |
| 中文关键词: 幽门螺旋杆菌；胃癌；基因变异；炎性 |
| 英文关键词: Helicobacter pylori (H. pylori); gastric cancer; gene variant; inflammatory |
| 基金项目:Supported by grant from the National Natural Sciences Foundation of China (No 81372931 and 81101550 ), the Natural Science Foundation of Hubei Province, China (No. 2012FFB05904) and the program for tackling key problems in science and technology in Wuhan (No.2013060602010253) |
| Author Name | Affiliation | E-mail | | Miao Li | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Jun Li | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Zhaozhen Qi | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Qiu Tang | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Xiangyang Wang | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Hongda Lu* | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | phlonda@163.com |
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| 中文摘要: |
| 幽门螺旋杆菌相关性胃癌是由幽门螺旋杆菌感染引起的慢性炎症过程，经过萎缩性胃炎、肠化生、胃酸过少、最终发展到胃癌。虽然世界上近于50%的人感染幽门螺旋杆菌，但仅有不到3%的感染者发生胃癌。幽门螺旋杆菌感染可以引起宿主体内数十年的急性和慢性炎症反应。宿主的炎性基因的变异对幽门螺旋杆菌相关性胃癌的易感性极其重要。现已发现的炎症基因的变异包括白介素基因家族，肿瘤坏死因子A，Toll样受体以及一些来自于全基因组关联研究发现的炎性基因多态性。这些基因变异与幽门螺旋杆菌相关性胃癌的发病风险的相关性有利于了解胃癌的发病机制，以便预防和攻克这一恶性肿瘤。 |
| 英文摘要: |
| Helicobacter pylori-related gastric cancer results from a chronic inflammatory process that arises from
atrophic gastritis, and develops into intestinal metaplasia, hyperplasia, and eventually gastric adenocarcinoma. Although approximately half of the world’s population is infected with Helicobacter pylori (H. pylori),
less than 3% of these infected individuals develop gastric cancer. H. pylori infection can cause both acute
and chronic inflammation, and may be present for decades within its host. Inflammatory gene variants are
particularly important factors that may influence a host’s susceptibility to H. pylori-related gastric cancer.
The inflammatory gene variants uncovered thus far include interleukin gene clusters, tumor necrosis factor-α, Toll-like receptors (TLRs), and inflammatory gene polymorphisms found in genome-wide association
studies (GWAS). The association between these gene variants and the risk of H. pylori-related gastric
cancer will aid in our understanding of the pathogenesis of gastric cancer in order to prevent and defeat
this malignancy. |
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