| Shanshan Chen,Shun Lu. Antiangiogenic agents combined with chemotherapy in non-small cell lung cancer. Oncol Transl Med, 2015, 1: 58-64. |
| 抗肿瘤血管药物联合化疗在非小细胞肺癌中的应用 |
| Antiangiogenic agents combined with chemotherapy in non-small cell lung cancer |
| Received:February 16, 2015 Revised:March 31, 2015 |
| DOI：10.1007/s10330-015-0072-1 |
| 中文关键词: 非小细胞肺癌，抗肿瘤血管药物，化疗，联合用药时序 |
| 英文关键词: non-small cell lung cancer (NSCLC); antiangiogenic agent; chemotherapy; combination schedule |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Shanshan Chen | Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | chenshan1234cool@163.com | | Shun Lu* | Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China | lushun131313@163.com |
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| 中文摘要: |
| 抗肿瘤血管治疗作为一种重要的靶向治疗策略，在晚期非小细胞肺癌的治疗中取得了一定的疗效。贝伐单抗是抗血管生成的单克隆抗体，是首个获批联合化疗用于非鳞型非小细胞肺癌一线治疗的抗血管药物。另一种抗血管药物，靶向酪氨酸激酶受体的小分子抑制剂联合化疗也为治疗晚期非小细胞肺癌带来了希望。但是，除了贝伐单抗，我们并没有从其他的抗血管药物联合化疗治疗非小细胞肺癌中获得预期的结果。从失败的临床试验来看，联合用药的时序问题可能是不可忽略的因素之一。本文综述了抗肿瘤血管药物联合化疗在非小细胞肺癌中的应用。 |
| 英文摘要: |
| As one of targeting therapies, antiangiogenic treatment has increasingly been studied for advanced non-small cell lung cancer(NSCLC)and it proves effectiveness in treatment of advanced NSCLC. Bevacizumab, a monoclonal antibody targeting angiogenesis, is the only approved antiangiogenic agent in combination with first-line chemotherapy for non-squamous NSCLC. Small molecule inhibitors targeting the tyrosine kinase receptor have also shown promise when combined with standard chemotherapeutic agents in patients with advanced NSCLC. However, except bevacizumab, not all other antiangiogenic agents showed significant benefits when combined with chemotherapy. As for the failures of most of other combinations, the combination schedule maybe an important reason overlooked in clinical trials. This article reviews the combination of angiogenic agents with chemotherapy in treatment of NSCLC . |
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