| Wentao Wei,Qinjiang Liu,Wei Yao. Factors influencing the presence of circulating differentiated thyroid cancer cells in the thyroidectomy perioperative period. Oncol Transl Med, 2015, 1: 208-211. |
| 分化型甲状腺癌手术前后外周血微转移的影响因素 |
| Factors influencing the presence of circulating differentiated thyroid cancer cells in the thyroidectomy perioperative period |
| Received:January 13, 2015 Revised:September 08, 2015 |
| DOI：10.1007/s10330-015-0059-y |
| 中文关键词: 甲状腺癌 流式细胞术 循环肿瘤细胞 |
| 英文关键词: thyroid cancer; flow cytometry; circulating tumor cell |
| 基金项目:甘肃省重点中医药项目 （GZK-2010-Z9） |
| Author Name | Affiliation | E-mail | | Wentao Wei | Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province | LIUQJ99@126.com | | Qinjiang Liu* | Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province | LIUQJ99@126.com | | Wei Yao | Department of Head and Neck Surgery,The Cancer Hospital of Gansu Province | LIUQJ99@126.com |
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| 中文摘要: |
| 目的 探讨分化型甲状腺癌围手术期循环血微转移存在状况及影响因素。方法 采用流式细胞术（FCM）对327例手术治疗的分化型甲状腺癌，围手术期检测外周血微转移并对其进行相关因素分析。结果 分化型甲状腺癌术后1周时循环血微转移阳性率高于术前、也高于术后4周，差异有显著性（P＜0.05）。手术前循环血微转移与肿瘤大小、淋巴结分期有关（P＜0.05），与肿瘤分化程度差异无显著性（P＞0.05）。手术后4周时循环血微转移阳性率仅与肿瘤分化程度有关（P＜0.05），与肿瘤大小、淋巴结分期差异均无显著性（P＞0.05）。结论 分化型甲状腺癌循环血微转移与肿瘤大小、淋巴结分期及手术刺激密切相关，肿瘤分化程度是循环血微转移阳性持续存在的主要因素。 |
| 英文摘要: |
| Objective: The aim of the study was to detect circulating differentiated thyroid cancer (DTC) micrometastasis and to investigate the factors influencing their presence in the perioperative thyroidectomy period.
Methods: DTC micrometastases in the peripheral blood were detected with flow cytometry, and patient clinical and pathological factors were analyzed in 327 DTC patients.
Results: Circulating blood micrometastases were present in the peripheral circulation at a higher rate 1 week postoperatively than preoperatively and at 4 weeks postoperatively (P < 0.05). The preoperative presence of circulating micrometastasis was associated with the size of the tumor and the presence of lymph node metastasis (P < 0.05), but was not related to the degree of tumor differentiation (P > 0.05). At 4 weeks postoperatively, the presence of circulating micrometastasis was not associated with tumor size or lymph node stage (P > 0.05), but was associated with poorly differentiated tumors (P < 0.05).
Conclusion: The presence of circulating DTC micrometastases correlates to tumor size, lymph node stage, and operative manipulation. The differentiation degree of the tumors were associated with the persistent presence of micrometastasis in the circulating blood. |
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