| Jun Zhu,Hao Wen,Xiaohua Wu. Clinicopathological characteristics and treatment of carcinosarcoma of the female genital tract. Oncol Transl Med, 2015, 1: 233-238. |
| 女性生殖道癌肉瘤临床病理及治疗研究进展 |
| Clinicopathological characteristics and treatment of carcinosarcoma of the female genital tract |
| Received:January 08, 2015 Revised:August 22, 2015 |
| DOI：10.1007/s10330-015-0056-1 |
| 中文关键词: 癌肉瘤；病理；治疗；预后 |
| 英文关键词: carcinosarcoma; pathology; treatment; prognosis |
| 基金项目: |
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| 中文摘要: |
| 性生殖道癌肉瘤是临床极为罕见但恶性程度极高的一类肿瘤，因组织成分同时含有癌和肉瘤两种成分，使其在治疗及预后方面不同于其他的妇科恶性肿瘤。临床上癌肉瘤的恶性程度更高、对放化疗的敏感性更低以及预后更差。目前对癌肉瘤的治疗方法主要以手术治疗为主，同时术后行辅助治疗，临床上仍主要将铂类作为其基础化疗药物。得益于癌肉瘤相关基因的异常表达，靶向治疗在改善癌肉瘤预后方面表现出新兴优势。 |
| 英文摘要: |
| Carcinosarcomas of the female genital tract are highly aggressive and rare tumors, differing from other malignant gynecological tumors in that they contain both malignant carcinomatous and sarcomatous elements. Because carcinosarcomas are rapidly progressive, less sensitive to chemotherapy or radiotherapy, and have a high probability of recurrence, patients with advanced uterine and ovarian carcinosarcomas have poorer survival than those with endometrial or high-grade serous carcinomas. Although the treatment strategies are controversial, a comprehensive management approach is recommended, which involves complete debulking surgery followed by adjuvant chemotherapy and/or radiotherapy. Molecular-targeted therapies are promising for the management and improvement in the overall survival of patients with carcinosarcomas. |
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