| Honghui Su. Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer. Oncol Transl Med, 2015, 1: 190-193. |
| 肝细胞生长因子／肝细胞生长因子受体通路 在肿瘤中的研究现状 |
| Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer |
| Received:December 28, 2014 Revised:July 30, 2015 |
| DOI：10.1007/s10330-014-0046-8 |
| 中文关键词: HGF/c-Met通路；靶向治疗；药物耐药；临床试验 |
| 英文关键词: HGF/c-Met pathway; targeted therapy; drug resistance; clinical trial |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Honghui Su* | Department of pharmacy Huabei Oilfield General Hospital Affiliated to Hebei Medical University | cutesusu@sogou.com |
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| 中文摘要: |
| HGF／c-Met通路在肿瘤的发生、发展中有重要作用，并参与肿瘤的侵袭和转移，使其成为肿瘤学研究的热点。本文就其作用机制、药物耐药及早期临床试验结果做一简要的阐述。 |
| 英文摘要: |
| The HGF/c-Met pathway plays an important role in the proliferation, invasion, angiogenesis, and metastasis
of tumors. With the successful development of small molecule c-Met kinase inhibitors, this signal pathway
has become the focus of oncology research. In this review, we discuss the basic mechanism, targeted
therapy, and early results of clinical trials of the HGF/c-Met pathway. |
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