| Honghui Su. Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer. Oncol Transl Med, 2015, 1: 190-193. |
| Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer |
| Received:December 28, 2014 Revised:July 30, 2015 |
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| KeyWord:HGF/c-Met pathway; targeted therapy; drug resistance; clinical trial |
| Author Name | Affiliation | E-mail | | Honghui Su | Department of pharmacy Huabei Oilfield General Hospital Affiliated to Hebei Medical University | cutesusu@sogou.com |
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| Abstract: |
| The HGF/c-Met pathway plays an important role in the proliferation, invasion, angiogenesis, and metastasis
of tumors. With the successful development of small molecule c-Met kinase inhibitors, this signal pathway
has become the focus of oncology research. In this review, we discuss the basic mechanism, targeted
therapy, and early results of clinical trials of the HGF/c-Met pathway. |
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