| Ranran Zhang,Wanqing Xie,Tao Han,Yongye Liu,Zhaozhe Liu,Fang Guo,Yaling Han,Zhenyu Ding,Yinghui Sun,Dongchu Ma,Xiaodong Xie. Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer. Oncol Transl Med, 2015, 1: 37-41. |
| 三阴乳腺癌患者应用DC/CIK免疫生物治疗联合辅助化疗的疗效观察 |
| Effect of dendritic cell/cytokine-induced killer cell immunobiological cancer therapy combined with adjuvant chemotherapy in patients with triple-negative breast cancer |
| Received:December 13, 2014 Revised:February 05, 2015 |
| DOI：10.1007/s10330-014-0037-9 |
| 中文关键词: 三阴乳腺癌；细胞因子诱导杀伤细胞；树突细胞；副作用；生活质量 |
| 英文关键词: triple-negative breast cancer (TNBC); cytokine-induced killer cell (CIK); dendritic cell (DC); side effect; quality of life (QoL) |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Ranran Zhang | Liaoning Medical University,General Hospital of Shenyang Military Region | chenxi.zhangran@163.com | | Wanqing Xie | The Basic Medical College of Liaoning University of Traditional Chinese Medicine | | | Tao Han | General Hospital of Shenyang Military Region | | | Yongye Liu | General Hospital of Shenyang Military Region | | | Zhaozhe Liu | General Hospital of Shenyang Military Region | | | Fang Guo | General Hospital of Shenyang Military Region | | | Yaling Han | General Hospital of Shenyang Military Region | | | Zhenyu Ding | General Hospital of Shenyang Military Region | | | Yinghui Sun | General Hospital of Shenyang Military Region | | | Dongchu Ma | General Hospital of Shenyang Military Region | | | Xiaodong Xie* | General Hospital of Shenyang Military Region | xxd_doctor@163.com |
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| 中文摘要: |
| 本研究的目的是观察DC/CIK免疫生物治疗联合辅助化疗对三阴乳腺癌的疗效。应用的方法是收集2010年1月到2013年10月在沈阳军区总医院诊断为三阴乳腺癌的49名病例。根据他们当时进行辅助化疗时是否接受了DC/CIK免疫生物治疗分为两组。DC/CIK组患者接受辅助化疗联合DC/CIK免疫生物治疗，而对照组只接受了辅助化疗。当6周期辅助化疗及6次DC/CIK免疫生物治疗结束后，分析DC/CIK组及对照组的生活质量、免疫学指标（CD3, CD4, CD8及NK的水平变化）、无病生存期以及辅助化疗和DC/CIK免疫生物治疗的副作用。通过这项研究我们认为DC/CIK免疫生物治疗可使三阴乳腺癌患者获益，并且没有明显的副作用，对于三阴乳腺癌患者而言是一种安全有效的治疗方法。 |
| 英文摘要: |
| Objective The aim of the present study was to investigate the effect of dendritic cell (DC)/cytokine-induced killer cell (CIK) immunobiological cancer therapy in patients with triple-negative breast cancer (TNBC) who underwent adjuvant chemotherapy.
Methods From January 2010 to October 2013, 120 patients with postoperative TNBC were recruited and included in the study. Patients were enrolled in one of two groups according to whether they accepted DC/CIK immunobiological cancer therapy during adjuvant chemotherapy; the patients in the DC/CIK group underwent adjuvant chemotherapy combined with DC/CIK immunobiological cancer therapy, and the control group underwent adjuvant chemotherapy alone. When six cycles of adjuvant chemotherapy and six cycles of DC/CIK immunobiological cancer therapy had been completed, differences between the two groups with regard to quality of life (QoL), immunological indicators (CD3, CD4, CD8, and NK cell levels), disease-free survival (DFS), and side effects of chemotherapy and DC/CIK treatment were evaluated.
Results In the DC/CIK group, the proportion of NK cells and CD3 and CD4 T-cell subgroups significantly increased, and the proportion of CD8 cells decreased when they were compared before and after DC/CIK therapy (P < 0.05). However, there were no significant changes in the control group. By the final follow-up, DFS of the treatment group and the control group was 38.4 and 34.2 months, respectively. The QoL improved in the patients treated with hemotherapy plus DC/CIK therapy compared with the patients treated with chemotherapy alone, and the difference between groups was significant (P < 0.05). The side effects of two groups were tolerable and not significantly different between the two groups.
Conclusion The DC/CIK treatment had potential benefits for patients with TNBC compared with the control group, and was not associated with any obvious side effects. Therefore, DC/CIK therapy is a safe and effective method for the treatment of TNBC. |
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