| Fuli Zhang,Xu Weidong,Jiang Huayong,Wang Yadi,Junmao Gao,Qingzhi Liu,Na Lu,Diandian Chen,Bo Yao,Jianping Chen,Heliang He. Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for treatment of cervical cancer. Oncol Transl Med, 2015, 1: 135-139. |
| 基于螺旋断层调强放疗的宫颈癌术后盆腔两种计划设计方法的剂量学分析 |
| Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for treatment of cervical cancer |
| Received:December 04, 2014 Revised:May 19, 2015 |
| DOI：10.1007/s10330-014-1434-9 |
| 中文关键词: 宫颈癌；螺旋断层调强放疗；剂量学 |
| 英文关键词: cervical neoplasm; helical tomotherapy; intensity-modulated radiotherapy (IMRT); dosimetry |
| 基金项目:全军军事医学计量专项课题（2011-JL2-005） |
| Author Name | Affiliation | E-mail | | Fuli Zhang | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | radiozfli@163.com | | Xu Weidong | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | | | Jiang Huayong | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | | | Wang Yadi* | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Junmao Gao | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Qingzhi Liu | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Na Lu | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Diandian Chen | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Bo Yao | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Jianping Chen | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Heliang He | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com |
|
| Hits: 8776 |
| Download times: 10504 |
| 中文摘要: |
| 目的: 比较两种螺旋断层调强放疗(IMRT)计划设计方法(对骨髓进行单独限量的BMS-HT，未对骨髓进行单独限量的HT)的异同点，探讨宫颈癌患者术后盆腔外照射血液毒性发生几率降低的可行性。方法: 对9例宫颈癌术后患者进行模拟CT增强扫描，在ADAC Pinnacle3 V9.2计划系统内勾画临床靶体积(CTV)，CTV均匀外扩1.0cm生成计划靶体积(PTV)，同时勾画小肠、直肠、膀胱、骨髓。进而设计出BMS-IMRT和IMRT的2种治疗计划，计划靶区处方剂量为45Gy，单次1.8Gy，计划要求95%计划靶区体积被处方剂量线包绕。采用Hi Art4.1.2治疗计划系统提供的卷积/迭加算法对两种放疗技术的治疗计划进行剂量计算，比较靶区和危及器官剂量分布、剂量体积直方图参数。结果: 两种计划的靶区剂量均匀性和适形性差异无显著性意义，但BMS-HT的适形度略优于HT计划，骨髓限量计划中的V5、V10、V20等剂量学参数分别较骨髓未限量计划中的相应参数降低0.06%、17.33%、22.19%、13.85%、16.46%，除小肠V30、膀胱V30、V40外，其它危及器官的受量差别不大。结论: 对于宫颈癌术后接受TOMO放疗患者，设计治疗计划时对骨髓采取限量措施有可能降低血液毒性发生概率和严重程度，从而提高患者生存质量。 |
| 英文摘要: |
| Objective The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy (BMS-IMRT) with intensity-modulated radiotherapy (IMRT) without entering the pelvic
bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy.
Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose
was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses
were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning
target volume homogeneity and conformity indices (HI and CI) as well as organ at risk dose and volume
parameters.
Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI.
V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%,
13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and
V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the
small bowel, bladder, and rectum.
Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy,
BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to
preventing acute hematologic toxicity |
|
View Full Text
Download reader HTML全文 |
| Close |
|
|
|