| Xiaochen Hu,Junqiang Yang,Ruijie Yang,Ruina Yang,Xinshuai Wang,Shegan Gao. MicroRNAs in tumor stem cells. Oncol Transl Med, 2015, 1: 92-96. |
| MicroRNAs在肿瘤干细胞中的研究进展 |
| MicroRNAs in tumor stem cells |
| Received:December 01, 2014 Revised:April 05, 2015 |
| DOI：10.1007/s10330-014-0031-2 |
| 中文关键词: miRNAs, 肿瘤干细胞, 干性 |
| 英文关键词: miRNAs; tumor stem cells; stemness |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Xiaochen Hu | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | 54846673@qq.com | | Junqiang Yang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | 369903863@qq.com | | Ruijie Yang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | 1032725019@qq.com | | Ruina Yang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | yrnwhw@foxmail.com | | Xinshuai Wang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | xshuaiw@126.com | | Shegan Gao* | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | gsg112258@126.com |
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| 中文摘要: |
| MicroRNAs(miRNAs)是一类非编码的小 RNA，在肿瘤的发生发展及侵袭转移中发挥着至关重要的作用。肿瘤干细胞是导致恶性肿瘤复发、转移和耐药的主要根源。研究发现 miRNAs可以促进或抑制肿瘤干细胞干性的维持，调控肿瘤干细胞的分化及自我更新，从而参与肿瘤的发生发展过程。本文详细介绍肿瘤干细胞中 miRNAs 的表达情况及调控机制，阐述其在肿瘤诊断及治疗中的潜在作用。 |
| 英文摘要: |
| MicroRNAs (miRNAs) are a class of non-coding RNAs that are believed to have a significant role in tumorigenesis and cancer metastasis. Cancer stem cells play a major role in tumor recurrence, metastasis, and drug resistance. Research has shown that miRNAs can promote or inhibit the stemness of cancer stem cells and regulate the differentiation and self-renewal of cancer stem cells. In this article, the phenotype and regulatory mechanisms of miRNAs in cancer stem cells will be described, together with an explanation of their potential role in tumor diagnosis and treatment. |
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